Detailed information of TA system TA069846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1440797..1441361
• Replicon: chromosome
• Accession: NZ_CP018363
• Organism: Mycobacterium avium subsp. hominissuis strain H87

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2A2ZLT9
• Locus tag: BS641_RS07215
• Protein ID: WP_023868517.1
• Coordinates: 1440990..1441361 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BS641_RS07210
• Protein ID: WP_011724021.1
• Coordinates: 1440797..1441003 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS641_RS07190	1436051..1437049	+	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
BS641_RS07195	1437073..1438281	-	1209	WP_179151735.1	hypothetical protein	-
BS641_RS07200	1438412..1439485	+	1074	WP_009975391.1	redox-regulated ATPase YchF	-
BS641_RS07205	1439685..1440629	+	945	WP_033720356.1	HNH endonuclease	-
BS641_RS07210	1440797..1441003	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BS641_RS07215	1440990..1441361	+	372	WP_023868517.1	type II toxin-antitoxin system VapC family toxin	Toxin
BS641_RS07220	1441461..1441901	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
BS641_RS07225	1441959..1442234	+	276	WP_033718665.1	hypothetical protein	-
BS641_RS07230	1442336..1442734	+	399	WP_023865349.1	VOC family protein	-
BS641_RS07235	1442803..1443186	+	384	WP_023868520.1	hypothetical protein	-
BS641_RS07240	1443256..1443609	+	354	WP_023868521.1	hypothetical protein	-
BS641_RS07245	1443766..1444131	+	366	Protein_1422	hypothetical protein	-
BS641_RS07250	1444715..1445038	+	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-
BS641_RS07255	1445043..1445726	-	684	WP_009975397.1	hypothetical protein	-
BS641_RS07260	1445844..1446041	+	198	WP_009975398.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13754.08 Da
• Isoelectric Point: 6.6032

>T69846 WP_023868517.1 NZ_CP018363:1440990-1441361 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T69846 NZ_CP018363:1440990-1441361 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT69846 WP_011724021.1 NZ_CP018363:1440797-1441003 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT69846 NZ_CP018363:1440797-1441003 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A2A2ZLT9