Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1029357..1030040 Replicon chromosome
Accession NZ_CP018363
Organism Mycobacterium avium subsp. hominissuis strain H87

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag BS641_RS05185 Protein ID WP_007168487.1
Coordinates 1029357..1029764 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag BS641_RS05190 Protein ID WP_033711258.1
Coordinates 1029768..1030040 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS641_RS05160 1024711..1025169 + 459 Protein_1010 IS30 family transposase -
BS641_RS05165 1025286..1025456 - 171 Protein_1011 carnitinyl-CoA dehydratase -
BS641_RS05170 1025568..1026800 - 1233 WP_011725525.1 IS256-like element IS1245 family transposase -
BS641_RS05175 1028629..1028934 - 306 WP_007168485.1 hypothetical protein -
BS641_RS05180 1028995..1029336 - 342 WP_007168486.1 hypothetical protein -
BS641_RS05185 1029357..1029764 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
BS641_RS05190 1029768..1030040 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BS641_RS05195 1030530..1030751 - 222 Protein_1017 transposase -
BS641_RS05200 1030795..1032738 - 1944 WP_007172497.1 tyrosine-type recombinase/integrase -
BS641_RS05205 1032735..1033784 - 1050 WP_007172498.1 tyrosine-type recombinase/integrase -
BS641_RS05210 1033853..1034914 - 1062 WP_007172499.1 IS256-like element IS1511 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1006282..1033784 27502
- flank IS/Tn - - 1033853..1034914 1061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T69844 WP_007168487.1 NZ_CP018363:c1029764-1029357 [Mycobacterium avium subsp. hominissuis]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T69844 NZ_CP018363:c1029764-1029357 [Mycobacterium avium subsp. hominissuis]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT69844 WP_033711258.1 NZ_CP018363:c1030040-1029768 [Mycobacterium avium subsp. hominissuis]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT69844 NZ_CP018363:c1030040-1029768 [Mycobacterium avium subsp. hominissuis]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References