Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 975398..976065 Replicon chromosome
Accession NZ_CP018363
Organism Mycobacterium avium subsp. hominissuis strain H87

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag BS641_RS04925 Protein ID WP_007168407.1
Coordinates 975398..975790 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag BS641_RS04930 Protein ID WP_007168406.1
Coordinates 975790..976065 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS641_RS04905 970663..971895 + 1233 WP_011725525.1 IS256-like element IS1245 family transposase -
BS641_RS26870 972328..972450 + 123 Protein_955 IS1595 family transposase -
BS641_RS04915 972711..974049 + 1339 Protein_956 DUF1298 domain-containing protein -
BS641_RS04920 974091..975250 + 1160 Protein_957 trehalose-phosphatase -
BS641_RS04925 975398..975790 - 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
BS641_RS04930 975790..976065 - 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BS641_RS04935 976218..977090 - 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
BS641_RS04940 977173..977876 + 704 Protein_961 histidine phosphatase family protein -
BS641_RS26875 977920..978060 + 141 WP_145958858.1 SDR family oxidoreductase -
BS641_RS04945 978012..978644 + 633 Protein_963 DDE-type integrase/transposase/recombinase -
BS641_RS04950 978783..979994 + 1212 Protein_964 ISL3 family transposase -
BS641_RS26565 980012..980245 + 234 Protein_965 transposase -
BS641_RS27425 980235..980561 + 327 WP_033711234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T69843 WP_007168407.1 NZ_CP018363:c975790-975398 [Mycobacterium avium subsp. hominissuis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T69843 NZ_CP018363:c975790-975398 [Mycobacterium avium subsp. hominissuis]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT69843 WP_007168406.1 NZ_CP018363:c976065-975790 [Mycobacterium avium subsp. hominissuis]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT69843 NZ_CP018363:c976065-975790 [Mycobacterium avium subsp. hominissuis]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References