69842

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4558657..4559276 Replicon chromosome
Accession NZ_CP018362
Organism Klebsiella oxytoca strain CAV1752

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag AGH21_RS24445 Protein ID WP_004099646.1
Coordinates 4558657..4558875 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag AGH21_RS24450 Protein ID WP_004129911.1
Coordinates 4558902..4559276 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGH21_RS24415 4554702..4554965 + 264 WP_004848323.1 type B 50S ribosomal protein L31 -
AGH21_RS24420 4554965..4555105 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AGH21_RS24425 4555102..4555800 - 699 WP_014228203.1 GNAT family N-acetyltransferase -
AGH21_RS24430 4555902..4557356 + 1455 WP_038424163.1 PLP-dependent aminotransferase family protein -
AGH21_RS24435 4557331..4557801 - 471 WP_014228205.1 YlaC family protein -
AGH21_RS24440 4557928..4558494 - 567 WP_038424164.1 maltose O-acetyltransferase -
AGH21_RS24445 4558657..4558875 - 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
AGH21_RS24450 4558902..4559276 - 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
AGH21_RS24455 4559757..4562903 - 3147 WP_014228207.1 multidrug efflux RND transporter permease subunit -
AGH21_RS24460 4562926..4564119 - 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T69842 WP_004099646.1 NZ_CP018362:c4558875-4558657 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T69842 NZ_CP018362:c4558875-4558657 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT69842 WP_004129911.1 NZ_CP018362:c4559276-4558902 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT69842 NZ_CP018362:c4559276-4558902 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References