69838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3093856..3094403 Replicon chromosome
Accession NZ_CP018362
Organism Klebsiella oxytoca strain CAV1752

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag AGH21_RS17430 Protein ID WP_014227299.1
Coordinates 3094095..3094403 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag AGH21_RS17425 Protein ID WP_014227298.1
Coordinates 3093856..3094092 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGH21_RS17410 3090063..3091229 + 1167 WP_014839828.1 multidrug effflux MFS transporter -
AGH21_RS17415 3091390..3092292 + 903 WP_038423879.1 N-acetylmuramic acid 6-phosphate etherase -
AGH21_RS17420 3092317..3093750 + 1434 WP_038423880.1 PTS N-acetylmuramic acid transporter subunit IIBC -
AGH21_RS17425 3093856..3094092 + 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
AGH21_RS17430 3094095..3094403 + 309 WP_014227299.1 CcdB family protein Toxin
AGH21_RS17435 3094554..3095456 + 903 WP_009654083.1 DMT family transporter -
AGH21_RS17440 3095460..3095717 - 258 WP_032718834.1 hypothetical protein -
AGH21_RS17445 3095717..3096681 - 965 Protein_2903 Rpn family recombination-promoting nuclease/putative transposase -
AGH21_RS17450 3096891..3097184 + 294 WP_014227302.1 hypothetical protein -
AGH21_RS17455 3097208..3098149 - 942 WP_014227303.1 LacI family transcriptional regulator -
AGH21_RS17460 3098444..3098755 + 312 WP_014227304.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T69838 WP_014227299.1 NZ_CP018362:3094095-3094403 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T69838 NZ_CP018362:3094095-3094403 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGTATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT69838 WP_014227298.1 NZ_CP018362:3093856-3094092 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT69838 NZ_CP018362:3093856-3094092 [Klebsiella oxytoca]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H5T3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References