Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 240305..241044 | Replicon | plasmid pCAV1752-278 |
| Accession | NZ_CP018361 | ||
| Organism | Klebsiella oxytoca strain CAV1752 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | AGH21_RS02105 | Protein ID | WP_076752153.1 |
| Coordinates | 240305..240790 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A5E1AWX8 |
| Locus tag | AGH21_RS02110 | Protein ID | WP_012540086.1 |
| Coordinates | 240778..241044 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AGH21_RS02075 | 236325..236741 | - | 417 | WP_076752145.1 | helix-turn-helix domain-containing protein | - |
| AGH21_RS02080 | 236738..237049 | - | 312 | WP_076752146.1 | type II toxin-antitoxin system HigB family toxin | - |
| AGH21_RS02085 | 237199..237411 | - | 213 | WP_076752148.1 | hypothetical protein | - |
| AGH21_RS02090 | 237519..237845 | - | 327 | WP_076752150.1 | hypothetical protein | - |
| AGH21_RS02095 | 238704..238862 | - | 159 | WP_076752152.1 | type I toxin-antitoxin system Hok family toxin | - |
| AGH21_RS02100 | 238934..240007 | + | 1074 | WP_013609528.1 | IS481-like element ISKpn28 family transposase | - |
| AGH21_RS02105 | 240305..240790 | - | 486 | WP_076752153.1 | GNAT family N-acetyltransferase | Toxin |
| AGH21_RS02110 | 240778..241044 | - | 267 | WP_012540086.1 | DUF1778 domain-containing protein | Antitoxin |
| AGH21_RS02115 | 241345..241668 | + | 324 | WP_013087171.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| AGH21_RS02120 | 241670..242383 | + | 714 | WP_013087170.1 | arsenical resistance protein ArsH | - |
| AGH21_RS02125 | 242392..242937 | + | 546 | WP_047365773.1 | sigma-70 family RNA polymerase sigma factor | - |
| AGH21_RS02130 | 243013..243375 | + | 363 | WP_013087168.1 | arsenic metallochaperone ArsD family protein | - |
| AGH21_RS02135 | 243402..245153 | + | 1752 | WP_187420813.1 | arsenical pump-driving ATPase | - |
| AGH21_RS02140 | 245278..245814 | + | 537 | WP_013087166.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..277616 | 277616 | |
| - | flank | IS/Tn | - | - | 238934..240007 | 1073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17838.68 Da Isoelectric Point: 10.0748
>T69826 WP_076752153.1 NZ_CP018361:c240790-240305 [Klebsiella oxytoca]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
Download Length: 486 bp
>T69826 NZ_CP018361:c240790-240305 [Klebsiella oxytoca]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10076.47 Da Isoelectric Point: 4.3721
>AT69826 WP_012540086.1 NZ_CP018361:c241044-240778 [Klebsiella oxytoca]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
Download Length: 267 bp
>AT69826 NZ_CP018361:c241044-240778 [Klebsiella oxytoca]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|