Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5095723..5096239 Replicon chromosome
Accession NZ_CP018356
Organism Klebsiella pneumoniae strain CAV1453

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AGG69_RS28450 Protein ID WP_002886902.1
Coordinates 5095955..5096239 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AGG69_RS28445 Protein ID WP_002886901.1
Coordinates 5095723..5095965 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGG69_RS28430 5091752..5092492 + 741 WP_002886899.1 KDGP aldolase family protein -
AGG69_RS28435 5092558..5093712 + 1155 WP_002886900.1 lactonase family protein -
AGG69_RS28440 5093735..5095645 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AGG69_RS28445 5095723..5095965 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AGG69_RS28450 5095955..5096239 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AGG69_RS28455 5096243..5096707 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AGG69_RS28460 5096948..5099086 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AGG69_RS28470 5099443..5100186 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AGG69_RS31205 5100189..5100362 - 174 WP_002886906.1 hypothetical protein -
AGG69_RS28480 5100447..5100755 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T69819 WP_002886902.1 NZ_CP018356:5095955-5096239 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T69819 NZ_CP018356:5095955-5096239 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT69819 WP_002886901.1 NZ_CP018356:5095723-5095965 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT69819 NZ_CP018356:5095723-5095965 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References