Detailed information of TA system TA069777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1341870..1342368
• Replicon: chromosome
• Accession: NZ_CP018347
• Organism: Streptococcus pneumoniae strain SWU02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BSL41_RS07455
• Protein ID: WP_001812387.1
• Coordinates: 1342114..1342368 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: BSL41_RS07450
• Protein ID: WP_000208080.1
• Coordinates: 1341870..1342112 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSL41_RS07430	1337692..1338867	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
BSL41_RS07435	1338922..1339626	+	705	WP_000722076.1	response regulator transcription factor	-
BSL41_RS07440	1339619..1340968	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
BSL41_RS07445	1340970..1341779	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
BSL41_RS07450	1341870..1342112	+	243	WP_000208080.1	hypothetical protein	Antitoxin
BSL41_RS07455	1342114..1342368	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSL41_RS07460	1342415..1343188	+	774	WP_000731129.1	ion transporter	-
BSL41_RS07465	1343504..1344850	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
BSL41_RS07475	1345159..1346145	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1343504..1344850	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T69777 WP_001812387.1 NZ_CP018347:1342114-1342368 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T69777 NZ_CP018347:1342114-1342368 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT69777 WP_000208080.1 NZ_CP018347:1341870-1342112 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT69777 NZ_CP018347:1341870-1342112 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7