Detailed information of TA system TA069765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4592654..4593170
• Replicon: chromosome
• Accession: NZ_CP018337
• Organism: Klebsiella pneumoniae isolate Kp_Goe_154414

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BB788_RS23775
• Protein ID: WP_040225317.1
• Coordinates: 4592654..4592938 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: BB788_RS23780
• Protein ID: WP_002886901.1
• Coordinates: 4592928..4593170 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB788_RS23745	4588126..4588434	-	309	WP_016947038.1	PTS sugar transporter subunit IIB	-
BB788_RS32640	4588519..4588692	+	174	WP_002886906.1	hypothetical protein	-
BB788_RS23755	4588695..4589438	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
BB788_RS23765	4589795..4591933	+	2139	WP_004222153.1	anaerobic ribonucleoside-triphosphate reductase	-
BB788_RS23770	4592186..4592650	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BB788_RS23775	4592654..4592938	-	285	WP_040225317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BB788_RS23780	4592928..4593170	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BB788_RS23785	4593248..4595157	-	1910	Protein_4386	BglG family transcription antiterminator	-
BB788_RS23790	4595180..4596334	-	1155	WP_073558056.1	lactonase family protein	-
BB788_RS23795	4596401..4597141	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11172.02 Da
• Isoelectric Point: 10.3787

>T69765 WP_040225317.1 NZ_CP018337:c4592938-4592654 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T69765 NZ_CP018337:c4592938-4592654 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT69765 WP_002886901.1 NZ_CP018337:c4593170-4592928 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT69765 NZ_CP018337:c4593170-4592928 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0