Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3893433..3894052 Replicon chromosome
Accession NZ_CP018337
Organism Klebsiella pneumoniae isolate Kp_Goe_154414

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BB788_RS20195 Protein ID WP_002892050.1
Coordinates 3893834..3894052 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BB788_RS20190 Protein ID WP_002892066.1
Coordinates 3893433..3893807 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB788_RS20180 3888585..3889778 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BB788_RS20185 3889801..3892947 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BB788_RS20190 3893433..3893807 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BB788_RS20195 3893834..3894052 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BB788_RS20200 3894211..3894777 + 567 WP_002892030.1 maltose O-acetyltransferase -
BB788_RS32570 3894749..3894889 - 141 WP_004147370.1 hypothetical protein -
BB788_RS20210 3894910..3895380 + 471 WP_002892026.1 YlaC family protein -
BB788_RS20215 3895355..3896806 - 1452 WP_073557971.1 PLP-dependent aminotransferase family protein -
BB788_RS20220 3896907..3897605 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
BB788_RS20225 3897602..3897742 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BB788_RS20230 3897742..3898005 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T69763 WP_002892050.1 NZ_CP018337:3893834-3894052 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T69763 NZ_CP018337:3893834-3894052 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT69763 WP_002892066.1 NZ_CP018337:3893433-3893807 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT69763 NZ_CP018337:3893433-3893807 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References