Detailed information of TA system TA069747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 2459258..2460288
• Replicon: chromosome
• Accession: NZ_CP018331
• Organism: Corynebacterium diphtheriae strain B-D-16-78

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: BS112_RS11940
• Protein ID: WP_070794874.1
• Coordinates: 2459258..2459677 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: BS112_RS11945
• Protein ID: WP_070794877.1
• Coordinates: 2459722..2460288 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS112_RS11915	2455914..2456768	+	855	WP_014303121.1	hypothetical protein	-
BS112_RS11920	2456761..2457669	-	909	WP_014310191.1	DUF1906 domain-containing protein	-
BS112_RS11925	2457798..2458998	-	1201	Protein_2254	cation:proton antiporter	-
BS112_RS11940	2459258..2459677	-	420	WP_070794874.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
BS112_RS11945	2459722..2460288	-	567	WP_070794877.1	SocA family protein	Antitoxin
BS112_RS12720	2460621..2460896	+	276	WP_014309249.1	hypothetical protein	-
BS112_RS11960	2461568..2461843	+	276	WP_014303127.1	hypothetical protein	-
BS112_RS11965	2461850..2462602	+	753	WP_014306660.1	precorrin-6A synthase (deacetylating)	-
BS112_RS11970	2462621..2462878	-	258	WP_070794878.1	mycoredoxin	-
BS112_RS11975	2462899..2463402	-	504	WP_072567275.1	dihydrofolate reductase	-
BS112_RS11980	2463402..2464214	-	813	WP_014318827.1	thymidylate synthase	-
BS112_RS11985	2464308..2465066	-	759	WP_070794880.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-93)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15477.61 Da
• Isoelectric Point: 8.2756

>T69747 WP_070794874.1 NZ_CP018331:c2459677-2459258 [Corynebacterium diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 420 bp

>T69747 NZ_CP018331:c2459677-2459258 [Corynebacterium diphtheriae]
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 21064.47 Da
• Isoelectric Point: 4.5581

>AT69747 WP_070794877.1 NZ_CP018331:c2460288-2459722 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
STALDSLEQAADDVATENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT69747 NZ_CP018331:c2460288-2459722 [Corynebacterium diphtheriae]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCACGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTACTGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG