Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3926454..3926967 Replicon chromosome
Accession NZ_CP018319
Organism Pseudomonas frederiksbergensis strain AS1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PFAS1_RS18270 Protein ID WP_076030029.1
Coordinates 3926454..3926738 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PFAS1_RS18275 Protein ID WP_076030030.1
Coordinates 3926728..3926967 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFAS1_RS18250 3922317..3923243 + 927 WP_076030025.1 hydroxymethylglutaryl-CoA lyase -
PFAS1_RS18255 3923431..3924762 + 1332 WP_076030026.1 MFS transporter -
PFAS1_RS18260 3924943..3925431 - 489 WP_076030027.1 DMT family transporter -
PFAS1_RS18265 3925509..3926420 + 912 WP_076030028.1 LysR family transcriptional regulator -
PFAS1_RS18270 3926454..3926738 - 285 WP_076030029.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFAS1_RS18275 3926728..3926967 - 240 WP_076030030.1 ribbon-helix-helix protein, CopG family Antitoxin
PFAS1_RS18280 3927184..3927912 + 729 WP_076031548.1 hypothetical protein -
PFAS1_RS18285 3927917..3928333 + 417 WP_076030031.1 fosfomycin resistance glutathione transferase -
PFAS1_RS18290 3928396..3929034 + 639 WP_074874239.1 LysE family translocator -
PFAS1_RS18295 3929121..3930470 + 1350 WP_076030032.1 sensor domain-containing diguanylate cyclase -
PFAS1_RS18300 3930588..3930746 + 159 WP_076030033.1 stress protein -
PFAS1_RS18305 3930820..3931323 + 504 WP_076030034.1 DUF4142 domain-containing protein -
PFAS1_RS18310 3931370..3931780 - 411 WP_076030035.1 low affinity iron permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10861.58 Da        Isoelectric Point: 10.8916

>T69719 WP_076030029.1 NZ_CP018319:c3926738-3926454 [Pseudomonas frederiksbergensis]
MRVEWLRTALKNLDDEAAYIAIENPKAAADFVQAILASVDHLARFPATGREGRLPGTREWVLPDRPYLIPYRVRQGRLQV
LRVFHTRRLPPASW

Download         Length: 285 bp

>T69719 NZ_CP018319:c3926738-3926454 [Pseudomonas frederiksbergensis]
ATGCGGGTTGAGTGGCTGCGTACTGCATTAAAGAATCTTGATGACGAAGCCGCTTATATAGCAATTGAGAATCCGAAAGC
CGCAGCGGACTTCGTCCAAGCCATCCTTGCCAGCGTCGATCATCTTGCGCGCTTCCCGGCAACCGGCCGTGAAGGCCGCC
TGCCCGGCACTCGAGAATGGGTCTTGCCAGACCGACCTTATCTCATTCCCTATCGAGTTCGCCAAGGACGCCTGCAAGTA
TTAAGGGTCTTCCATACCAGGCGTCTTCCGCCTGCCAGTTGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8597.67 Da        Isoelectric Point: 4.2958

>AT69719 WP_076030030.1 NZ_CP018319:c3926967-3926728 [Pseudomonas frederiksbergensis]
MSVMSLRLPDEIADTLASLSKATGRSKSFLAVDALREYLAREAWQIEEIQKALKEADAGDFATPEEVNAIADKWTANAG

Download         Length: 240 bp

>AT69719 NZ_CP018319:c3926967-3926728 [Pseudomonas frederiksbergensis]
ATGTCCGTCATGTCTTTGCGTCTGCCAGACGAAATCGCCGATACCCTCGCCAGCCTTTCCAAGGCCACTGGCCGCAGCAA
GTCATTTCTCGCAGTGGATGCTCTGCGTGAGTATCTCGCGAGGGAAGCCTGGCAAATCGAGGAAATTCAGAAAGCACTGA
AAGAAGCCGATGCTGGTGACTTCGCAACGCCAGAAGAAGTGAATGCAATCGCCGACAAGTGGACAGCCAATGCGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References