Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2203679..2204243 Replicon chromosome
Accession NZ_CP018319
Organism Pseudomonas frederiksbergensis strain AS1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PFAS1_RS10230 Protein ID WP_076029082.1
Coordinates 2203679..2204008 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PFAS1_RS10235 Protein ID WP_076029083.1
Coordinates 2203998..2204243 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFAS1_RS10210 2198776..2199336 - 561 WP_074872461.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
PFAS1_RS10215 2199476..2201005 + 1530 WP_076029079.1 apoptosis inducing factor family protein -
PFAS1_RS10220 2201125..2202630 - 1506 WP_076029080.1 YdgA family protein -
PFAS1_RS10225 2202958..2203596 - 639 WP_076029081.1 NADH:ubiquinone oxidoreductase subunit N -
PFAS1_RS10230 2203679..2204008 - 330 WP_076029082.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFAS1_RS10235 2203998..2204243 - 246 WP_076029083.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PFAS1_RS10240 2204355..2204600 - 246 WP_074872451.1 DUF2789 domain-containing protein -
PFAS1_RS10245 2204738..2205199 - 462 WP_008148137.1 YbaK/EbsC family protein -
PFAS1_RS10250 2205397..2205927 + 531 WP_076031514.1 serine protease -
PFAS1_RS10255 2205930..2206688 + 759 WP_008148132.1 slipin family protein -
PFAS1_RS10260 2207045..2207428 + 384 WP_076029084.1 hypothetical protein -
PFAS1_RS10265 2207550..2207789 - 240 Protein_1980 hypothetical protein -
PFAS1_RS29470 2207761..2207853 - 93 Protein_1981 efflux RND transporter periplasmic adaptor subunit -
PFAS1_RS10270 2208143..2208831 + 689 Protein_1982 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-69)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12578.51 Da        Isoelectric Point: 10.5350

>T69716 WP_076029082.1 NZ_CP018319:c2204008-2203679 [Pseudomonas frederiksbergensis]
MTYKLEFLPSARKEWDKLGHTLREQFKKKLAERLELPRVPSDSLHGMPDCYKIKLRSSGYRLVYEVIDERVVVSVVAVGK
RERSAVYDRAKKRGSWESGRTQGPNSGKP

Download         Length: 330 bp

>T69716 NZ_CP018319:c2204008-2203679 [Pseudomonas frederiksbergensis]
ATGACCTATAAGCTCGAATTCCTGCCGTCTGCACGCAAGGAGTGGGACAAACTGGGTCATACATTGCGCGAGCAATTCAA
AAAGAAACTGGCAGAGCGACTTGAACTCCCGCGAGTGCCCTCAGATTCACTCCATGGAATGCCTGACTGCTACAAAATCA
AGCTGCGGTCATCGGGGTACAGGTTGGTGTATGAGGTTATTGATGAGCGTGTAGTCGTTTCCGTGGTGGCGGTGGGTAAG
CGTGAGCGCAGCGCTGTTTATGATCGAGCCAAGAAACGTGGCAGCTGGGAAAGCGGACGAACGCAAGGCCCGAACTCCGG
CAAACCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8850.18 Da        Isoelectric Point: 4.7124

>AT69716 WP_076029083.1 NZ_CP018319:c2204243-2203998 [Pseudomonas frederiksbergensis]
MQNVLADLAVSVSELKKNPSAVLSGAHGGPVAVLNHNRVMGYMVPADVFEAMMERLDDLELAEIVRSRRHETPVPVNLDD
L

Download         Length: 246 bp

>AT69716 NZ_CP018319:c2204243-2203998 [Pseudomonas frederiksbergensis]
ATGCAAAATGTTCTGGCCGACCTGGCTGTCAGTGTGTCTGAGCTGAAGAAAAACCCATCTGCGGTTTTGAGCGGCGCCCA
TGGTGGGCCCGTTGCAGTGCTGAATCACAATCGAGTAATGGGCTACATGGTCCCGGCCGATGTTTTCGAGGCCATGATGG
AACGCCTCGATGACCTTGAATTGGCAGAAATCGTTCGCTCGCGCAGGCATGAAACGCCGGTCCCGGTAAATCTGGATGAC
CTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References