Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2069896..2070533 Replicon chromosome
Accession NZ_CP018319
Organism Pseudomonas frederiksbergensis strain AS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PFAS1_RS09615 Protein ID WP_076028998.1
Coordinates 2070126..2070533 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PFAS1_RS09610 Protein ID WP_033058311.1
Coordinates 2069896..2070126 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFAS1_RS09575 2065456..2065728 + 273 WP_008149405.1 oxidative damage protection protein -
PFAS1_RS09585 2065992..2066441 - 450 WP_076028994.1 hypothetical protein -
PFAS1_RS09590 2066704..2067762 + 1059 Protein_1847 DUF1016 family protein -
PFAS1_RS09595 2067832..2068806 + 975 WP_076028995.1 alpha/beta fold hydrolase -
PFAS1_RS09600 2068843..2069259 + 417 WP_076028996.1 hypothetical protein -
PFAS1_RS09605 2069266..2069718 + 453 WP_076028997.1 hypothetical protein -
PFAS1_RS09610 2069896..2070126 + 231 WP_033058311.1 antitoxin Antitoxin
PFAS1_RS09615 2070126..2070533 + 408 WP_076028998.1 tRNA(fMet)-specific endonuclease VapC Toxin
PFAS1_RS09620 2070611..2072002 - 1392 WP_076028999.1 GABA permease -
PFAS1_RS09625 2072569..2073342 + 774 WP_007897462.1 ABC transporter ATP-binding protein -
PFAS1_RS09630 2073356..2074102 + 747 WP_074872681.1 ABC transporter substrate-binding protein -
PFAS1_RS09635 2074180..2074872 + 693 WP_076029000.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15077.39 Da        Isoelectric Point: 6.6381

>T69715 WP_076028998.1 NZ_CP018319:2070126-2070533 [Pseudomonas frederiksbergensis]
MIKYMLDTNICIFTIKNKPQIVREAFNRHDGQLCISAVTLMELIYGAEKSAAPEKNLAVIEGFAARLEVLPFDNEAASHT
GMIRSELAKAGTPIGPYDHMIAGHARSRGFIVVTNNLREFERVPGLRVEDWVHPD

Download         Length: 408 bp

>T69715 NZ_CP018319:2070126-2070533 [Pseudomonas frederiksbergensis]
ATGATCAAATACATGCTCGATACCAACATCTGCATCTTCACCATAAAGAACAAACCGCAAATCGTACGAGAAGCTTTCAA
CCGTCATGACGGGCAGCTATGTATCAGCGCCGTCACGCTGATGGAGTTGATCTACGGTGCGGAAAAATCAGCAGCACCCG
AAAAAAACCTCGCTGTGATCGAGGGTTTTGCGGCACGCCTTGAAGTCTTGCCTTTCGACAATGAAGCAGCCTCGCATACC
GGAATGATTCGATCCGAGCTGGCCAAGGCTGGCACGCCTATCGGGCCCTACGACCACATGATTGCCGGCCACGCACGTTC
ACGCGGATTCATAGTGGTAACCAACAACCTGCGAGAATTTGAACGGGTTCCAGGGCTACGCGTAGAAGACTGGGTTCACC
CCGATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8576.57 Da        Isoelectric Point: 4.3569

>AT69715 WP_033058311.1 NZ_CP018319:2069896-2070126 [Pseudomonas frederiksbergensis]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVNVVAIGRARIITPADETWDSWFDGDGVSADFMTDREQPADQERESF

Download         Length: 231 bp

>AT69715 NZ_CP018319:2069896-2070126 [Pseudomonas frederiksbergensis]
ATGGAACAGACCACCCTTTTCATGAGCAATCGAAGCCAGGCTGTCCGCCTCCCCAAAGCTGTTGCGATGCCAAGCGACGT
GAAACGAGTCAACGTAGTTGCCATCGGCAGAGCTCGCATCATCACTCCCGCAGATGAAACATGGGACAGCTGGTTCGACG
GGGATGGCGTAAGTGCAGACTTCATGACCGATCGTGAACAACCCGCCGATCAGGAGCGTGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References