Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1724513..1725109 Replicon chromosome
Accession NZ_CP018319
Organism Pseudomonas frederiksbergensis strain AS1

Toxin (Protein)


Gene name relE Uniprot ID A0A1P8ET10
Locus tag PFAS1_RS08135 Protein ID WP_074873405.1
Coordinates 1724513..1724815 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1P8ET08
Locus tag PFAS1_RS08140 Protein ID WP_074873403.1
Coordinates 1724819..1725109 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFAS1_RS08115 1719842..1721239 - 1398 WP_083671729.1 precorrin-3B synthase -
PFAS1_RS08120 1721294..1722505 + 1212 WP_076028803.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
PFAS1_RS08125 1722498..1723595 + 1098 WP_076028804.1 cobalt-precorrin-5B (C(1))-methyltransferase -
PFAS1_RS08130 1723592..1724308 + 717 WP_076028805.1 cobalt-precorrin-6A reductase -
PFAS1_RS08135 1724513..1724815 + 303 WP_074873405.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFAS1_RS08140 1724819..1725109 + 291 WP_074873403.1 putative addiction module antidote protein Antitoxin
PFAS1_RS08145 1725209..1725607 + 399 WP_076028806.1 DUF2946 domain-containing protein -
PFAS1_RS08150 1725656..1726135 + 480 WP_076028807.1 copper chaperone PCu(A)C -
PFAS1_RS08155 1726156..1726584 + 429 WP_076028808.1 DUF2946 domain-containing protein -
PFAS1_RS08160 1726776..1728893 + 2118 WP_076028809.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-93)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11410.06 Da        Isoelectric Point: 8.8773

>T69714 WP_074873405.1 NZ_CP018319:1724513-1724815 [Pseudomonas frederiksbergensis]
MIDFERSRAFADWLDSLKDIIGKARIIARLRAAEHGNFGDCEPVGGAVYEMRVHYGPGYRMYFTRRGEVVYLLLVGGDKS
TQKRDIKRAIQMAQNIGNEE

Download         Length: 303 bp

>T69714 NZ_CP018319:1724513-1724815 [Pseudomonas frederiksbergensis]
ATGATCGACTTCGAACGATCCCGAGCATTTGCTGACTGGCTCGACTCACTGAAAGACATCATTGGCAAAGCTCGCATCAT
TGCCAGGCTCCGAGCTGCCGAGCATGGAAATTTTGGTGATTGCGAACCGGTGGGTGGAGCTGTTTATGAAATGCGTGTGC
ATTACGGTCCTGGCTACAGGATGTATTTCACCCGCCGAGGTGAAGTGGTTTATCTGCTGTTGGTGGGCGGTGACAAGTCG
ACTCAAAAACGAGACATCAAACGCGCCATTCAAATGGCGCAAAACATCGGTAATGAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10354.90 Da        Isoelectric Point: 4.8096

>AT69714 WP_074873403.1 NZ_CP018319:1724819-1725109 [Pseudomonas frederiksbergensis]
MAEQFTRFDAAEFLKTPEEMAAYLDACFEEDAGDGVLIRAALNDIARAKGMTQIARDAGLGRESLYKALGSTGNPEFATI
MKVMKALGLRLHASAL

Download         Length: 291 bp

>AT69714 NZ_CP018319:1724819-1725109 [Pseudomonas frederiksbergensis]
ATGGCCGAACAATTCACCCGTTTCGATGCCGCCGAATTTCTAAAAACACCAGAAGAAATGGCGGCTTACCTGGACGCCTG
TTTTGAAGAAGATGCTGGCGACGGAGTGCTCATACGTGCAGCCCTTAACGACATAGCCCGAGCAAAGGGCATGACACAGA
TTGCCCGTGACGCGGGGCTGGGTCGTGAAAGTCTGTACAAAGCATTGGGCAGCACTGGCAACCCGGAATTCGCGACTATC
ATGAAAGTGATGAAAGCATTAGGTCTGCGCCTGCATGCCAGCGCTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1P8ET10

Antitoxin

Source ID Structure
AlphaFold DB A0A1P8ET08

References