Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2190902..2192457 Replicon chromosome
Accession NZ_CP018312
Organism Vibrio rotiferianus strain B64D1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BSZ04_RS19180 Protein ID WP_088881165.1
Coordinates 2191141..2192457 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BSZ04_RS19175 Protein ID WP_088881164.1
Coordinates 2190902..2191141 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSZ04_RS19160 2186932..2188122 - 1191 WP_088881161.1 restriction endonuclease subunit S -
BSZ04_RS19165 2188112..2189629 - 1518 WP_088881162.1 type I restriction-modification system subunit M -
BSZ04_RS19170 2189674..2189868 - 195 WP_088881163.1 hypothetical protein -
BSZ04_RS19175 2190902..2191141 + 240 WP_088881164.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BSZ04_RS19180 2191141..2192457 + 1317 WP_088881165.1 type II toxin-antitoxin system HipA family toxin Toxin
BSZ04_RS19185 2192493..2193013 - 521 Protein_1914 hypothetical protein -
BSZ04_RS19190 2193124..2193360 + 237 WP_071235593.1 helix-turn-helix domain-containing protein -
BSZ04_RS19195 2193550..2194203 + 654 WP_069539757.1 hypothetical protein -
BSZ04_RS19200 2194263..2195303 - 1041 WP_088880544.1 IS481 family transposase -
BSZ04_RS19205 2195480..2196238 - 759 WP_088881166.1 hypothetical protein -
BSZ04_RS19210 2196244..2196714 - 471 WP_088881167.1 hypothetical protein -
BSZ04_RS19215 2196715..2197365 - 651 WP_088881168.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2174811..2204733 29922
- flank IS/Tn - - 2194263..2195303 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-400)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49414.70 Da        Isoelectric Point: 6.5938

>T69709 WP_088881165.1 NZ_CP018312:2191141-2192457 [Vibrio rotiferianus]
MQQLNAYMNGELVGTLTKQKNGSHEFQYDSSWLNNDKARPLSLSLKLQLPVISSDAVINYFDNLLPDNIAIRNRIVARYQ
TASNQPFDLLKEIGKDSVGAIALLPSEQPYVNHELSYECLSEERLEKILAAHNSDIPLGMIKEEEDFRISVAGAQEKTAL
LKVADDWCLPKGNTPTSHIIKLPIGEIKQPNSTLDLTDSVENEFICIELARELGFNVPQVEIINTANFKAIAVERFDRRW
IREHTQLLRLPQEDICQAKGIPSSIKYENDGGPGIKEIMELLKGSSNALQDQYNFMKFQVFQWAIGAIDGHAKNYSIFIE
KQGSYRLTPFYDILSAFPITGKKGLDIRKLKLAMGLKATRGKKYQISKIYPHHFLDTAASVDFSTEQMQKILNDMQIELP
EAVKRLQARLPEGFPVEVSSAIFEHSLKMVKKLSITSS

Download         Length: 1317 bp

>T69709 NZ_CP018312:2191141-2192457 [Vibrio rotiferianus]
ATGCAGCAACTTAATGCTTACATGAATGGAGAACTCGTTGGAACTCTAACCAAGCAAAAGAACGGCTCTCATGAGTTTCA
ATACGATAGCTCTTGGCTAAACAACGATAAAGCTCGCCCATTATCTTTATCACTTAAGTTGCAGTTACCTGTGATCTCCT
CTGATGCGGTTATCAACTACTTCGACAACTTGCTGCCTGACAACATTGCAATACGCAATCGAATCGTTGCTCGCTATCAA
ACCGCTTCCAACCAACCATTCGATCTACTAAAAGAGATCGGTAAAGACAGCGTTGGCGCAATCGCCCTGCTTCCCTCAGA
ACAACCATACGTGAATCACGAACTCTCGTATGAATGCCTAAGCGAGGAAAGACTAGAGAAAATCTTAGCAGCCCATAATT
CTGATATTCCACTGGGTATGATTAAAGAGGAGGAAGATTTTCGAATCTCTGTCGCAGGTGCTCAAGAGAAAACCGCACTT
TTAAAAGTTGCCGATGATTGGTGTCTGCCAAAAGGCAACACGCCAACAAGTCACATAATCAAACTGCCAATTGGGGAAAT
TAAACAGCCCAACTCAACATTAGATCTGACCGACAGCGTTGAAAATGAGTTCATCTGTATCGAATTAGCTAGAGAGCTAG
GCTTTAATGTCCCACAAGTCGAAATCATCAATACTGCAAATTTTAAAGCCATTGCTGTTGAGCGCTTTGATCGACGCTGG
ATTAGAGAACACACACAACTCCTGCGGCTTCCTCAAGAAGACATCTGTCAGGCTAAAGGAATACCATCTTCCATAAAATA
CGAAAATGATGGGGGACCTGGAATCAAAGAGATCATGGAGTTATTAAAAGGGTCTTCTAATGCTCTGCAAGACCAATATA
ACTTCATGAAGTTTCAAGTATTTCAGTGGGCAATTGGTGCAATTGATGGGCATGCTAAAAACTATTCTATCTTTATTGAA
AAGCAAGGCAGTTACCGATTAACACCATTTTATGACATCTTATCCGCCTTCCCGATTACAGGGAAAAAAGGGCTAGATAT
ACGAAAGCTCAAACTCGCGATGGGATTAAAGGCCACTCGTGGTAAGAAGTACCAGATAAGTAAAATCTACCCCCACCACT
TCTTAGATACCGCAGCTTCAGTGGATTTTAGTACGGAACAAATGCAAAAAATTTTAAATGACATGCAAATCGAACTTCCT
GAAGCGGTTAAACGTTTGCAGGCTAGGCTTCCAGAAGGTTTCCCCGTAGAAGTATCTTCTGCGATATTCGAACACTCGCT
CAAGATGGTCAAAAAGCTCAGTATCACAAGTTCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9092.44 Da        Isoelectric Point: 5.0668

>AT69709 WP_088881164.1 NZ_CP018312:2190902-2191141 [Vibrio rotiferianus]
MIYSPQQLANVLLLIRQKNGWTQSEVAKRVGIKQATISNFENKPEKATISTMFKIVQALDLTVKIETRTENEIVDEEDW

Download         Length: 240 bp

>AT69709 NZ_CP018312:2190902-2191141 [Vibrio rotiferianus]
ATGATTTATAGCCCGCAGCAATTAGCTAATGTTTTACTATTAATTCGCCAAAAAAATGGGTGGACTCAGTCCGAGGTAGC
GAAACGAGTTGGCATAAAACAAGCAACCATTTCAAACTTCGAAAATAAGCCTGAAAAAGCAACCATTTCAACCATGTTCA
AGATCGTTCAAGCTTTAGACCTAACGGTAAAAATTGAAACACGAACTGAGAACGAAATTGTCGATGAGGAAGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References