Detailed information of TA system TA069707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/YefM(antitoxin)
• Location: 575883..576445
• Replicon: chromosome
• Accession: NZ_CP018312
• Organism: Vibrio rotiferianus strain B64D1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BSZ04_RS11715
• Protein ID: WP_088880447.1
• Coordinates: 575883..576185 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7Y4E0G7
• Locus tag: BSZ04_RS11720
• Protein ID: WP_045394064.1
• Coordinates: 576185..576445 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSZ04_RS11695	571531..572898	+	1368	WP_088880445.1	glycerol-3-phosphate transporter	-
BSZ04_RS11700	572953..574008	+	1056	WP_088880446.1	glycerophosphodiester phosphodiesterase	-
BSZ04_RS11705	574432..575463	-	1032	WP_005391708.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
BSZ04_RS11715	575883..576185	-	303	WP_088880447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSZ04_RS11720	576185..576445	-	261	WP_045394064.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BSZ04_RS11725	576757..577740	-	984	WP_005427312.1	GGGtGRT protein	-
BSZ04_RS11730	577764..578456	-	693	WP_005427365.1	iron-sulfur cluster assembly scaffold protein	-
BSZ04_RS11735	578949..579248	-	300	WP_005380208.1	YebG family protein	-
BSZ04_RS11740	579396..580313	-	918	WP_088880448.1	LysR family transcriptional regulator	-
BSZ04_RS11745	580426..581400	+	975	WP_088880449.1	TDT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11594.42 Da
• Isoelectric Point: 8.8452

>T69707 WP_088880447.1 NZ_CP018312:c576185-575883 [Vibrio rotiferianus]
MTQYKLSPAAQTDLIDIRRYTLENWGDAQWTNYFGELKQAMTLLASNELIGIDMPELGTGYCRFPLKHHVIYYIRKPDHI
VIAAVLGRNMSPAKHFQRQL

Nucleotide

• Length: 303 bp

>T69707 NZ_CP018312:c576185-575883 [Vibrio rotiferianus]
ATGACACAATACAAACTTTCTCCCGCAGCCCAAACGGACCTAATCGACATTCGCCGTTATACGCTTGAAAATTGGGGAGA
CGCACAGTGGACCAATTATTTTGGAGAGCTCAAACAAGCAATGACGTTGTTAGCTAGCAATGAGTTGATTGGGATTGATA
TGCCGGAGCTAGGAACCGGTTACTGCCGCTTTCCGTTAAAGCATCATGTGATTTATTACATAAGAAAACCTGACCACATT
GTTATTGCTGCAGTCTTAGGGCGTAACATGTCACCAGCTAAGCACTTTCAGCGACAATTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9648.06 Da
• Isoelectric Point: 4.6437

>AT69707 WP_045394064.1 NZ_CP018312:c576445-576185 [Vibrio rotiferianus]
MQSLTANTAKTKFGDLLMKVQREPVQISKNGSPVAVVMSCKEYEELEALKMAMVKSRFEQAERDIVNGDLVDGERFMSEL
DSGKFD

Nucleotide

• Length: 261 bp

>AT69707 NZ_CP018312:c576445-576185 [Vibrio rotiferianus]
ATGCAATCGTTAACAGCAAATACCGCAAAAACCAAATTTGGTGACTTACTGATGAAAGTTCAGCGAGAGCCAGTTCAAAT
CAGCAAAAATGGTTCACCTGTGGCAGTTGTCATGTCATGTAAAGAATACGAGGAGCTTGAAGCCTTAAAGATGGCGATGG
TGAAATCACGTTTTGAACAAGCGGAACGAGACATCGTGAATGGAGATTTGGTGGATGGCGAACGCTTCATGAGCGAATTA
GATTCAGGCAAGTTTGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y4E0G7