Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2961428..2961956 Replicon chromosome
Accession NZ_CP018308
Organism Vibrio mediterranei strain QT6D1

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag BSZ05_RS13965 Protein ID WP_005377002.1
Coordinates 2961428..2961718 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag BSZ05_RS13970 Protein ID WP_005377003.1
Coordinates 2961708..2961956 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSZ05_RS13940 2956995..2957408 + 414 WP_047690452.1 hypothetical protein -
BSZ05_RS13945 2957561..2958367 + 807 WP_088877219.1 hypothetical protein -
BSZ05_RS13950 2958945..2959811 + 867 WP_088877220.1 hypothetical protein -
BSZ05_RS13955 2959922..2960344 + 423 WP_088877221.1 GNAT family N-acetyltransferase -
BSZ05_RS13965 2961428..2961718 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSZ05_RS13970 2961708..2961956 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BSZ05_RS27130 2962031..2962099 + 69 WP_074531725.1 DUF3265 domain-containing protein -
BSZ05_RS13975 2962161..2962757 + 597 WP_088877213.1 class I SAM-dependent methyltransferase -
BSZ05_RS13980 2962898..2963320 + 423 WP_088877223.1 hypothetical protein -
BSZ05_RS13985 2963445..2964125 + 681 WP_088877224.1 hypothetical protein -
BSZ05_RS13990 2964149..2964238 + 90 WP_197697715.1 DUF3265 domain-containing protein -
BSZ05_RS13995 2964277..2965056 + 780 WP_088877225.1 hypothetical protein -
BSZ05_RS14000 2965220..2965993 + 774 WP_088877226.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2955497..2968448 12951
- inside Integron - - 2948336..2969128 20792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T69706 WP_005377002.1 NZ_CP018308:c2961718-2961428 [Vibrio mediterranei]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T69706 NZ_CP018308:c2961718-2961428 [Vibrio mediterranei]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTGGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT69706 WP_005377003.1 NZ_CP018308:c2961956-2961708 [Vibrio mediterranei]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT69706 NZ_CP018308:c2961956-2961708 [Vibrio mediterranei]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTGCCTGCCGAAGCTTACGAAATGATGA
TGGACAGACTCGAAGATCTGGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References