Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5126046..5126703 Replicon chromosome
Accession NZ_CP018307
Organism Klebsiella variicola strain X39

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BC497_RS25445 Protein ID WP_002916310.1
Coordinates 5126293..5126703 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BC497_RS25440 Protein ID WP_002916312.1
Coordinates 5126046..5126312 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC497_RS25420 5122437..5123165 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
BC497_RS25425 5123216..5123527 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
BC497_RS25430 5123691..5124350 + 660 WP_008806429.1 hemolysin III family protein -
BC497_RS25435 5124817..5125800 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
BC497_RS25440 5126046..5126312 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BC497_RS25445 5126293..5126703 + 411 WP_002916310.1 protein YgfX Toxin
BC497_RS25450 5126710..5127231 - 522 WP_008806427.1 flavodoxin FldB -
BC497_RS25455 5127332..5128228 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
BC497_RS25460 5128251..5128964 + 714 WP_087653414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BC497_RS25465 5128970..5130703 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T69705 WP_002916310.1 NZ_CP018307:5126293-5126703 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T69705 NZ_CP018307:5126293-5126703 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT69705 WP_002916312.1 NZ_CP018307:5126046-5126312 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT69705 NZ_CP018307:5126046-5126312 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References