Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3632278..3632854 Replicon chromosome
Accession NZ_CP018307
Organism Klebsiella variicola strain X39

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag BC497_RS17990 Protein ID WP_012542979.1
Coordinates 3632567..3632854 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag BC497_RS17985 Protein ID WP_087652864.1
Coordinates 3632278..3632580 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC497_RS17960 3627686..3628750 - 1065 WP_008807596.1 DUF2955 domain-containing protein -
BC497_RS17965 3628740..3629807 - 1068 WP_008807597.1 HlyD family secretion protein -
BC497_RS17970 3629814..3630278 - 465 WP_087652863.1 MarR family transcriptional regulator -
BC497_RS17975 3630444..3630608 - 165 WP_008807599.1 DUF1127 domain-containing protein -
BC497_RS17980 3630786..3632198 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
BC497_RS17985 3632278..3632580 - 303 WP_087652864.1 BrnA antitoxin family protein Antitoxin
BC497_RS17990 3632567..3632854 - 288 WP_012542979.1 BrnT family toxin Toxin
BC497_RS17995 3633021..3633440 - 420 WP_008807601.1 FosA family fosfomycin resistance glutathione transferase -
BC497_RS18000 3633434..3634342 - 909 WP_012542980.1 LysR family transcriptional regulator -
BC497_RS18005 3634429..3635211 + 783 WP_016160218.1 NAD(P)H-dependent oxidoreductase -
BC497_RS18010 3635249..3636205 - 957 WP_016160217.1 ABC transporter permease -
BC497_RS18015 3636202..3637173 - 972 WP_008807605.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T69699 WP_012542979.1 NZ_CP018307:c3632854-3632567 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T69699 NZ_CP018307:c3632854-3632567 [Klebsiella variicola]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11325.97 Da        Isoelectric Point: 9.5746

>AT69699 WP_087652864.1 NZ_CP018307:c3632580-3632278 [Klebsiella variicola]
MSMVKHKRDNTAALTAKCDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp

>AT69699 NZ_CP018307:c3632580-3632278 [Klebsiella variicola]
ATGAGCATGGTTAAACATAAACGCGACAATACGGCGGCGCTTACCGCTAAGTGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTAAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References