Detailed information of TA system TA069695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1524605..1526169
• Replicon: chromosome
• Accession: NZ_CP018307
• Organism: Klebsiella variicola strain X39

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: BC497_RS07410
• Protein ID: WP_087653150.1
• Coordinates: 1524605..1525903 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1F2MCN9
• Locus tag: BC497_RS07415
• Protein ID: WP_008804920.1
• Coordinates: 1525903..1526169 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BC497_RS07395	1519670..1522171	+	2502	WP_087653149.1	fimbrial biogenesis outer membrane usher protein	-
BC497_RS07400	1522159..1523163	+	1005	WP_063105598.1	type 1 fimbrial protein	-
BC497_RS07405	1523296..1524588	+	1293	WP_012968243.1	glycoside hydrolase family 10 protein	-
BC497_RS07410	1524605..1525903	-	1299	WP_087653150.1	type II toxin-antitoxin system HipA family toxin	Toxin
BC497_RS07415	1525903..1526169	-	267	WP_008804920.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
BC497_RS07420	1526556..1526882	-	327	WP_008804921.1	hydroxyisourate hydrolase	-
BC497_RS07425	1526879..1527379	-	501	WP_008804922.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
BC497_RS07430	1527357..1528736	-	1380	WP_012968246.1	purine permease	-
BC497_RS07435	1529082..1530236	+	1155	WP_023322603.1	FAD-dependent urate hydroxylase HpxO	-
BC497_RS07440	1530217..1531140	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48087.27 Da
• Isoelectric Point: 7.9109

>T69695 WP_087653150.1 NZ_CP018307:c1525903-1524605 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLAVPEAEIITTPRIRALAVTRFDRRWAQEGRVLL
RLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLLPGGSYRLT
PFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVPQAIESARR
TLPADFSTHVWRAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1299 bp

>T69695 NZ_CP018307:c1525903-1524605 [Klebsiella variicola]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGCACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTACCCGACAGCCCGCAGGTCCGCGATCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTGGGACGGGATAGCGTAGGGGCGGTGACTCTGCTACCGCCGGG
GGAAGAGGCGCACCTCGAGGGGTTGCGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCCTACCAGT
CGGATATCCCTCTCGGGATGATTACCGGCCAGGATGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGGGCACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCTAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGGTGCCGGAGGCAGAGA
TTATCACCACGCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTTGACCGGCGCTGGGCGCAGGAGGGACGGGTGCTGCTG
CGTCTGCCGCAGGAGGATCTGTGTCAGGCCTTTGGCATCCCGTCGTCGATGAAATATGAATCTGACGGCGGGCCGGGTAT
TGCGGCAATCATGGCCTTTCTGCTGGGCTCCAGTGAAGCCCTGAAAGATCGCGCAGACTTTATGAAATTCATGGTTTTTC
AGTGGCTGGTTGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTGCCCGGTGGCAGCTACCGTCTAACG
CCGTTCTACGACATCATTTCGGCGTTTCCGGTGCTGGGAGGCACGGGACTGCATCTGCGCGACCTGAAGCTGTCGATGGG
GCTCAATGCCACAAAAGGGCGGAAAACAGAGATTAACGCCATCTATCCGCGTCATTTTCTGGCAACCGCCAAAGCGGTGA
ACTTTCCTGGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCGCAGGCAATCGAAAGCGCTCGCCGG
ACGCTGCCGGCGGACTTTTCCACCCACGTCTGGCGGGCCATTACGGAAAATATGCTGAAGCTGCACGCCCGCCTGCAGCA
AGGGCTGCAGGCGTTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.30 Da
• Isoelectric Point: 8.5912

>AT69695 WP_008804920.1 NZ_CP018307:c1526169-1525903 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT69695 NZ_CP018307:c1526169-1525903 [Klebsiella variicola]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTATCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACACTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTAGGGGTGGTGATGACGCTGAACGCCAAAGCCACAGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1F2MCN9