Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2333465..2333981 Replicon chromosome
Accession NZ_CP018306
Organism Klebsiella pneumoniae strain Klebsiella pneumoniae 459 isolate 459

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag A9493_RS11755 Protein ID WP_004192395.1
Coordinates 2333697..2333981 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag A9493_RS11750 Protein ID WP_004192397.1
Coordinates 2333465..2333707 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9493_RS11735 2329493..2330233 + 741 WP_002886899.1 KDGP aldolase family protein -
A9493_RS11740 2330300..2331454 + 1155 WP_004178372.1 lactonase family protein -
A9493_RS11745 2331477..2333387 + 1911 WP_004152270.1 BglG family transcription antiterminator -
A9493_RS11750 2333465..2333707 + 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A9493_RS11755 2333697..2333981 + 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9493_RS11760 2333985..2334449 - 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A9493_RS11765 2334757..2336895 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
A9493_RS11770 2337252..2337995 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A9493_RS27540 2337998..2338171 - 174 WP_002886906.1 hypothetical protein -
A9493_RS11775 2338256..2338564 + 309 WP_004192389.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T69673 WP_004192395.1 NZ_CP018306:2333697-2333981 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T69673 NZ_CP018306:2333697-2333981 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT69673 WP_004192397.1 NZ_CP018306:2333465-2333707 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT69673 NZ_CP018306:2333465-2333707 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References