69667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 902923..903580 Replicon chromosome
Accession NZ_CP018306
Organism Klebsiella pneumoniae strain Klebsiella pneumoniae 459 isolate 459

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A9493_RS04470 Protein ID WP_002916310.1
Coordinates 902923..903333 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A9493_RS04475 Protein ID WP_002916312.1
Coordinates 903314..903580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9493_RS04450 898923..900656 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
A9493_RS04455 900662..901375 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A9493_RS04460 901398..902294 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A9493_RS04465 902395..902916 + 522 WP_002916308.1 flavodoxin FldB -
A9493_RS04470 902923..903333 - 411 WP_002916310.1 protein YgfX Toxin
A9493_RS04475 903314..903580 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A9493_RS04480 903826..904809 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
A9493_RS04485 904960..905619 - 660 WP_002916317.1 hemolysin III family protein -
A9493_RS04490 905783..906094 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
A9493_RS04495 906144..906872 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A9493_RS04500 906991..908424 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T69667 WP_002916310.1 NZ_CP018306:c903333-902923 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T69667 NZ_CP018306:c903333-902923 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT69667 WP_002916312.1 NZ_CP018306:c903580-903314 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT69667 NZ_CP018306:c903580-903314 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References