Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3690161..3690835 Replicon chromosome
Accession NZ_CP018305
Organism Mycobacterium tuberculosis strain M0018684-2

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BOM22_RS18090 Protein ID WP_003417282.1
Coordinates 3690161..3690589 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BOM22_RS18095 Protein ID WP_003417286.1
Coordinates 3690593..3690835 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOM22_RS18065 3685983..3686384 - 402 WP_003417264.1 cytidine deaminase -
BOM22_RS18070 3686525..3686959 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BOM22_RS18075 3686956..3687390 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BOM22_RS18080 3687519..3689291 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BOM22_RS18085 3689291..3690082 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
BOM22_RS18090 3690161..3690589 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BOM22_RS18095 3690593..3690835 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BOM22_RS18100 3690957..3691571 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BOM22_RS18105 3691568..3692233 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BOM22_RS18110 3692234..3692767 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BOM22_RS18115 3692764..3693138 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T69663 WP_003417282.1 NZ_CP018305:c3690589-3690161 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T69663 NZ_CP018305:c3690589-3690161 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT69663 WP_003417286.1 NZ_CP018305:c3690835-3690593 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT69663 NZ_CP018305:c3690835-3690593 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References