Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 2857037..2857746 | Replicon | chromosome |
Accession | NZ_CP018304 | ||
Organism | Mycobacterium tuberculosis strain M0002959-6 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ26 |
Locus tag | BOK72_RS13885 | Protein ID | WP_003413164.1 |
Coordinates | 2857037..2857450 (+) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | BOK72_RS13890 | Protein ID | WP_003413167.1 |
Coordinates | 2857489..2857746 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BOK72_RS13850 | 2852090..2853295 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
BOK72_RS13855 | 2853403..2853717 | + | 315 | WP_009937839.1 | hypothetical protein | - |
BOK72_RS13860 | 2854013..2855224 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
BOK72_RS13870 | 2855351..2856010 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
BOK72_RS13875 | 2856007..2856669 | + | 663 | WP_003900848.1 | hypothetical protein | - |
BOK72_RS13880 | 2856666..2856944 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
BOK72_RS13885 | 2857037..2857450 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
BOK72_RS13890 | 2857489..2857746 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
BOK72_RS13895 | 2857743..2858120 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
BOK72_RS13900 | 2858136..2858510 | - | 375 | WP_003413177.1 | hypothetical protein | - |
BOK72_RS13905 | 2858610..2859005 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
BOK72_RS13910 | 2859002..2859247 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
BOK72_RS13920 | 2859658..2860077 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
BOK72_RS13925 | 2860089..2860898 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
BOK72_RS13930 | 2860895..2862148 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
BOK72_RS13935 | 2862141..2862653 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T69590 WP_003413164.1 NZ_CP018304:2857037-2857450 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T69590 NZ_CP018304:2857037-2857450 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT69590 WP_003413167.1 NZ_CP018304:2857489-2857746 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT69590 NZ_CP018304:2857489-2857746 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ26 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |