Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2190922..2191466 | Replicon | chromosome |
| Accession | NZ_CP018304 | ||
| Organism | Mycobacterium tuberculosis strain M0002959-6 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | BOK72_RS10585 | Protein ID | WP_003409896.1 |
| Coordinates | 2190922..2191218 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | BOK72_RS10590 | Protein ID | WP_003409899.1 |
| Coordinates | 2191215..2191466 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BOK72_RS10530 | 2185955..2186305 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| BOK72_RS10535 | 2186316..2187218 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| BOK72_RS10540 | 2187239..2187430 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| BOK72_RS10545 | 2187431..2187727 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| BOK72_RS10550 | 2187967..2188182 | + | 216 | WP_003409878.1 | antitoxin | - |
| BOK72_RS10555 | 2188179..2188490 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| BOK72_RS21980 | 2188464..2188985 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| BOK72_RS10565 | 2188960..2189337 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| BOK72_RS10570 | 2189379..2189828 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| BOK72_RS10575 | 2189825..2190370 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| BOK72_RS10580 | 2190259..2190873 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| BOK72_RS10585 | 2190922..2191218 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BOK72_RS10590 | 2191215..2191466 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| BOK72_RS10595 | 2191453..2191947 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| BOK72_RS10600 | 2192107..2192514 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| BOK72_RS10605 | 2192518..2192790 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| BOK72_RS10610 | 2192823..2194043 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| BOK72_RS10625 | 2194942..2195739 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T69579 WP_003409896.1 NZ_CP018304:c2191218-2190922 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T69579 NZ_CP018304:c2191218-2190922 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT69579 WP_003409899.1 NZ_CP018304:c2191466-2191215 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT69579 NZ_CP018304:c2191466-2191215 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |