Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3094309..3094879 | Replicon | chromosome |
Accession | NZ_CP018302 | ||
Organism | Mycobacterium tuberculosis strain I0004000-1 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | BOJ12_RS15225 | Protein ID | WP_003414166.1 |
Coordinates | 3094309..3094665 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | BOJ12_RS15230 | Protein ID | WP_003901465.1 |
Coordinates | 3094649..3094879 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BOJ12_RS15205 | 3089761..3091449 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
BOJ12_RS15210 | 3091453..3091779 | - | 327 | WP_003414157.1 | hypothetical protein | - |
BOJ12_RS15215 | 3091952..3092539 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
BOJ12_RS15220 | 3092558..3094207 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
BOJ12_RS15225 | 3094309..3094665 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
BOJ12_RS15230 | 3094649..3094879 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
BOJ12_RS15235 | 3094922..3095965 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
BOJ12_RS21665 | 3096156..3096431 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
BOJ12_RS21670 | 3096607..3096861 | - | 255 | WP_003917684.1 | hypothetical protein | - |
BOJ12_RS15255 | 3097009..3097413 | + | 405 | WP_009938577.1 | hypothetical protein | - |
BOJ12_RS15260 | 3097410..3097601 | + | 192 | WP_003414184.1 | hypothetical protein | - |
BOJ12_RS15265 | 3097665..3098954 | + | 1290 | Protein_2882 | transposase family protein | - |
BOJ12_RS15270 | 3099188..3099445 | + | 258 | WP_003899489.1 | hypothetical protein | - |
BOJ12_RS15275 | 3099550..3099861 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T69475 WP_003414166.1 NZ_CP018302:c3094665-3094309 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T69475 NZ_CP018302:c3094665-3094309 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT69475 WP_003901465.1 NZ_CP018302:c3094879-3094649 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT69475 NZ_CP018302:c3094879-3094649 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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