Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2224576..2225162 Replicon chromosome
Accession NZ_CP018302
Organism Mycobacterium tuberculosis strain I0004000-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BOJ12_RS10795 Protein ID WP_070892640.1
Coordinates 2224576..2224920 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag BOJ12_RS10800 Protein ID WP_003410014.1
Coordinates 2224914..2225162 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOJ12_RS10755 2220282..2220881 + 600 WP_003409989.1 L-lysine exporter -
BOJ12_RS10760 2221297..2221725 + 429 WP_003906713.1 cellulose-binding protein -
BOJ12_RS10765 2221951..2222490 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
BOJ12_RS10775 2223010..2223570 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
BOJ12_RS10780 2223567..2223908 - 342 WP_003410003.1 DUF2384 domain-containing protein -
BOJ12_RS10785 2223994..2224251 + 258 WP_003410006.1 hypothetical protein -
BOJ12_RS10790 2224152..2224487 - 336 WP_003410009.1 dehydrogenase -
BOJ12_RS10795 2224576..2224920 - 345 WP_070892640.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
BOJ12_RS10800 2224914..2225162 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
BOJ12_RS10805 2225262..2227211 - 1950 WP_023643701.1 cadmium-translocating P-type ATPase -
BOJ12_RS10810 2227158..2229497 + 2340 Protein_2046 HAD-IC family P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12214.12 Da        Isoelectric Point: 9.8887

>T69461 WP_070892640.1 NZ_CP018302:c2224920-2224576 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQADPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T69461 NZ_CP018302:c2224920-2224576 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGGCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT69461 WP_003410014.1 NZ_CP018302:c2225162-2224914 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT69461 NZ_CP018302:c2225162-2224914 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References