69347

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2853674..2854383 Replicon chromosome
Accession NZ_CP018300
Organism Mycobacterium tuberculosis strain I0002353-6

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag BOM19_RS13870 Protein ID WP_003413164.1
Coordinates 2853674..2854087 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag BOM19_RS13875 Protein ID WP_003413167.1
Coordinates 2854126..2854383 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOM19_RS13835 2848727..2849932 - 1206 WP_003413027.1 chorismate synthase -
BOM19_RS13840 2850040..2850354 + 315 WP_009937839.1 hypothetical protein -
BOM19_RS13845 2850650..2851861 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
BOM19_RS13855 2851988..2852647 + 660 WP_014585545.1 LppA family lipoprotein -
BOM19_RS13860 2852644..2853306 + 663 WP_003900848.1 hypothetical protein -
BOM19_RS13865 2853303..2853581 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
BOM19_RS13870 2853674..2854087 + 414 WP_003413164.1 PIN domain nuclease Toxin
BOM19_RS13875 2854126..2854383 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
BOM19_RS13880 2854380..2854757 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
BOM19_RS13885 2854773..2855147 - 375 WP_003413177.1 hypothetical protein -
BOM19_RS13890 2855247..2855642 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
BOM19_RS13895 2855639..2855884 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
BOM19_RS13905 2856295..2856714 - 420 WP_003413190.1 A24 family peptidase -
BOM19_RS13910 2856726..2857535 - 810 WP_003413193.1 shikimate dehydrogenase -
BOM19_RS13915 2857532..2858785 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
BOM19_RS13920 2858778..2859290 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T69347 WP_003413164.1 NZ_CP018300:2853674-2854087 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T69347 NZ_CP018300:2853674-2854087 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT69347 WP_003413167.1 NZ_CP018300:2854126-2854383 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT69347 NZ_CP018300:2854126-2854383 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References