Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1592365..1593497 Replicon chromosome
Accession NZ_CP018260
Organism Acinetobacter haemolyticus strain XH900

Toxin (Protein)


Gene name - Uniprot ID A0A2K8PX24
Locus tag BSR56_RS07850 Protein ID WP_017396077.1
Coordinates 1592365..1593129 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID N9FA41
Locus tag BSR56_RS07855 Protein ID WP_004639219.1
Coordinates 1593126..1593497 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR56_RS07825 1588273..1589130 + 858 WP_004639225.1 3-deoxy-8-phosphooctulonate synthase -
BSR56_RS07830 1589222..1590511 + 1290 WP_004639224.1 phosphopyruvate hydratase -
BSR56_RS07835 1590641..1591006 + 366 WP_004639223.1 cell division protein FtsB -
BSR56_RS07840 1590996..1591703 + 708 WP_100833646.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
BSR56_RS07845 1591830..1592306 + 477 WP_005090442.1 hypothetical protein -
BSR56_RS07850 1592365..1593129 - 765 WP_017396077.1 RES family NAD+ phosphorylase Toxin
BSR56_RS07855 1593126..1593497 - 372 WP_004639219.1 DUF2384 domain-containing protein Antitoxin
BSR56_RS07860 1593713..1594126 + 414 WP_005080585.1 YeeE/YedE family protein -
BSR56_RS07865 1594128..1594541 + 414 WP_005090445.1 YeeE/YedE family protein -
BSR56_RS07870 1594556..1595428 + 873 WP_075315624.1 MBL fold metallo-hydrolase -
BSR56_RS07875 1595596..1596294 + 699 WP_100833647.1 phosphoglycerate mutase family protein -
BSR56_RS07880 1596436..1596696 + 261 WP_005080592.1 hypothetical protein -
BSR56_RS07885 1596823..1597407 + 585 WP_100833648.1 uracil-DNA glycosylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(73-121)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29082.00 Da        Isoelectric Point: 5.8003

>T69299 WP_017396077.1 NZ_CP018260:c1593129-1592365 [Acinetobacter haemolyticus]
MTAIEQNLWQSCEGNKQVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGAPKKKTIRTEHTLFSVGYHCHKGIRLQSPPFDQYLDLI
AHPTNYSYAQLLGTAMRNEGIEIFEYPSARASDHATCVGLFTAEHFSQNSPLDREQWFCDIGAEEVIFKAVEGSDIVRFE
LSQFLQQGIFPMPA

Download         Length: 765 bp

>T69299 NZ_CP018260:c1593129-1592365 [Acinetobacter haemolyticus]
ATGACCGCCATTGAGCAAAATTTATGGCAAAGTTGTGAAGGAAACAAACAAGTCTCACCTTTATCAGGTACTTTATATCG
TCTAGTTGAAAGCCAAGAACAAATTGCAACTAGGCAGTTGGTTGATACTTTAGAAGAACAAGCATTGCTCGAGGATATGT
TAGAGTTAGTTAAACCACCATATCCTCCAAAGTCAGAGCATTTACATTACCTACTCAAAACACCATTTCGTTATCCACCG
TTAAAATGGGGATCACGTTTCGGTCGTACTTTTGAACCCAGTATTTTTTATGGTGGGTGTAGTGTCAATGTGACATTGGC
TGAATCAGCTTATTATCGCTTTGTATTCTGGCACTCAATGGATGGTGCGCCAAAGAAAAAAACGATACGCACTGAGCATA
CTCTATTTTCAGTAGGCTATCACTGCCATAAGGGTATTCGTTTACAATCCCCTCCTTTTGACCAATATCTGGATCTAATT
GCTCATCCTACAAATTATAGTTATGCACAACTATTAGGCACAGCAATGCGGAATGAAGGAATTGAGATCTTTGAATATCC
GTCAGCTCGAGCAAGTGATCATGCTACCTGTGTCGGATTATTCACCGCAGAGCATTTCAGCCAAAATAGCCCTTTAGATC
GAGAACAATGGTTCTGTGACATAGGTGCTGAAGAAGTTATATTTAAAGCAGTAGAAGGATCTGATATCGTTCGCTTTGAA
TTATCGCAGTTTTTACAACAAGGTATTTTTCCAATGCCTGCATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13291.58 Da        Isoelectric Point: 10.4005

>AT69299 WP_004639219.1 NZ_CP018260:c1593497-1593126 [Acinetobacter haemolyticus]
MSALLKQPADKKVVLAKAVLSAAEQLDLKQVQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFLNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Download         Length: 372 bp

>AT69299 NZ_CP018260:c1593497-1593126 [Acinetobacter haemolyticus]
ATGAGTGCATTATTAAAACAACCCGCAGATAAAAAAGTAGTTCTTGCAAAAGCAGTACTCAGTGCCGCTGAGCAACTTGA
TTTAAAGCAAGTACAACTTGCCGCCATTTTAGGTGTACATCGCACAGCGATTAGTCGATTGAAAAATAATCCTGAATTAG
ATCCCGCATCTAAACAAGGTGAGTTAGCATTGCTTCTTATTCGTTTATCACGCGCATTGTATGCACTAACTGGCGGAGAC
ACGGATTGGATGCGTCATTTTTTGAACACACCAAATCGTGTTACAGGTGGTATTCCTGTTGAACAAATTGAAAGTATAAG
TGGACTGGTTTCAGTTCTTCAATTTGTCGATGCGATTCGAGGTAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PX24

Antitoxin

Source ID Structure
AlphaFold DB N9FA41

References