Detailed information of TA system TA069297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 337991..338611
• Replicon: chromosome
• Accession: NZ_CP018260
• Organism: Acinetobacter haemolyticus strain XH900

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BSR56_RS01650
• Protein ID: WP_100833133.1
• Coordinates: 338201..338611 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1L6KJB8
• Locus tag: BSR56_RS01645
• Protein ID: WP_008941147.1
• Coordinates: 337991..338200 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR56_RS01615	333998..334210	+	213	WP_017395601.1	addiction module protein	-
BSR56_RS01620	334207..334485	+	279	WP_075314557.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BSR56_RS01625	334624..335514	+	891	WP_100833132.1	metal-dependent hydrolase	-
BSR56_RS01630	335688..336278	+	591	WP_004641306.1	LemA family protein	-
BSR56_RS01635	336303..337364	+	1062	WP_005087014.1	TPM domain-containing protein	-
BSR56_RS01640	337358..337918	+	561	WP_075314563.1	TPM domain-containing protein	-
BSR56_RS01645	337991..338200	+	210	WP_008941147.1	antitoxin	Antitoxin
BSR56_RS01650	338201..338611	+	411	WP_100833133.1	tRNA(fMet)-specific endonuclease VapC	Toxin
BSR56_RS01655	338761..339951	+	1191	WP_005088500.1	Fic family protein	-
BSR56_RS01660	340435..341523	-	1089	Protein_313	IS4 family transposase	-
BSR56_RS01665	341604..342116	+	513	Protein_314	hypothetical protein	-
BSR56_RS01675	342435..342794	+	360	WP_005018086.1	DUF2384 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	306889..430846	123957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15374.79 Da
• Isoelectric Point: 8.8849

>T69297 WP_100833133.1 NZ_CP018260:338201-338611 [Acinetobacter haemolyticus]
MLKYMLDTNIVIYTMKQRPLGVKERFNAVSTQLCVSSITVAELIFGAENSQMPEKNLKVVEDFLSRLQILDYGVDAAIQY
GNIKAQLKRKGQPIGENDLHIAAHARSRGLILVTNNTREFERVPALQIENWLKESG

Nucleotide

• Length: 411 bp

>T69297 NZ_CP018260:338201-338611 [Acinetobacter haemolyticus]
ATGCTGAAATATATGCTCGATACCAATATTGTGATTTATACAATGAAACAAAGACCACTGGGGGTTAAAGAAAGGTTTAA
TGCTGTTTCAACACAACTCTGTGTTAGTAGTATCACTGTTGCGGAATTAATTTTTGGGGCGGAAAATAGCCAAATGCCCG
AGAAGAATTTAAAAGTTGTAGAGGATTTTTTATCACGATTGCAAATTTTGGATTATGGCGTAGATGCTGCAATCCAATAT
GGAAATATTAAAGCTCAGCTAAAAAGAAAAGGTCAACCGATTGGCGAGAATGATCTACATATCGCAGCTCATGCGAGAAG
TAGGGGATTGATTTTGGTGACCAATAATACAAGAGAGTTTGAGCGTGTGCCTGCATTACAGATAGAAAACTGGTTGAAAG
AAAGCGGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8155.02 Da
• Isoelectric Point: 4.2702

>AT69297 WP_008941147.1 NZ_CP018260:337991-338200 [Acinetobacter haemolyticus]
MNNRTQAVRLPSIYRFSETTQKVFVRQVGVERVISPVEQVWDSFFEDPELQLSDDFERGEQISAERESF

Nucleotide

• Length: 210 bp

>AT69297 NZ_CP018260:337991-338200 [Acinetobacter haemolyticus]
ATGAATAATCGTACCCAAGCAGTAAGACTACCGAGTATTTATCGTTTTTCTGAAACAACTCAAAAAGTTTTTGTGCGACA
GGTGGGGGTTGAGCGAGTGATTAGCCCAGTAGAACAGGTTTGGGATAGTTTTTTCGAAGATCCTGAGTTACAACTTTCAG
ATGACTTTGAGCGTGGCGAACAAATTTCAGCAGAGAGAGAGTCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6KJB8