Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 131176..131798 Replicon chromosome
Accession NZ_CP018260
Organism Acinetobacter haemolyticus strain XH900

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BSR56_RS00635 Protein ID WP_100833062.1
Coordinates 131176..131571 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BSR56_RS00640 Protein ID WP_100833063.1
Coordinates 131568..131798 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR56_RS00605 126588..127499 - 912 WP_005087216.1 alpha/beta hydrolase -
BSR56_RS00610 127689..128126 + 438 WP_100833059.1 DUF2147 domain-containing protein -
BSR56_RS00615 128223..128573 - 351 WP_100833060.1 Spx/MgsR family RNA polymerase-binding regulatory protein -
BSR56_RS00620 129013..129837 - 825 WP_008942133.1 exodeoxyribonuclease III -
BSR56_RS00625 129879..130529 + 651 WP_075314386.1 orotate phosphoribosyltransferase -
BSR56_RS00630 130588..131040 - 453 WP_100833061.1 ABZJ_00895 family protein -
BSR56_RS00635 131176..131571 - 396 WP_100833062.1 type II toxin-antitoxin system VapC family toxin Toxin
BSR56_RS00640 131568..131798 - 231 WP_100833063.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BSR56_RS00645 131926..132645 - 720 WP_100833064.1 SDR family oxidoreductase -
BSR56_RS00650 132960..133487 + 528 WP_000537572.1 plasmid pRiA4b ORF-3 family protein -
BSR56_RS00655 134021..134323 + 303 WP_100834230.1 hypothetical protein -
BSR56_RS00660 134571..134852 + 282 WP_100833065.1 hypothetical protein -
BSR56_RS00665 134860..135792 - 933 WP_020846310.1 IS5 family transposase -
BSR56_RS00675 136209..136412 - 204 WP_100833067.1 DUF3565 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 134860..135729 869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14898.19 Da        Isoelectric Point: 6.7181

>T69296 WP_100833062.1 NZ_CP018260:c131571-131176 [Acinetobacter haemolyticus]
MIYLLDTNICIYVINNKPQHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILAYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALAMDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T69296 NZ_CP018260:c131571-131176 [Acinetobacter haemolyticus]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTCATCAACAATAAGCCTCAACACGTTTTTGAACGCTTTAAGCA
ATATCAACTCGGCCAGCTTGCGATTTCAAGTATCACGGCATCTGAGCTGGCTTTCGGTGTAGAGAAGTCTGGATCTGAAC
GCAATAAACAGGCGTTAAACAAGTTTTTGTCACCTTTAGAGATCTTAGCTTACGATGAACAGGCCATTTGGCATTACGCC
AAATTACGCCAGAATCTTCAATCTACAGGTAAACCGATTGGCAGCTTAGATATGCTGATTGCTGCTCATGCTTTAGCGAT
GGATGTTGTCTTAGTCACGAACAATACCAAAGAATTTGAACGTATTGATGGTCTAAAGTTAGAAAATTGGGTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.11 Da        Isoelectric Point: 5.1106

>AT69296 WP_100833063.1 NZ_CP018260:c131798-131568 [Acinetobacter haemolyticus]
MEIAKVFKTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDIMLEAINEFEVGFQLERADQGEQFREEFK

Download         Length: 231 bp

>AT69296 NZ_CP018260:c131798-131568 [Acinetobacter haemolyticus]
ATGGAAATTGCGAAAGTATTTAAAACAGGCCGAAGTCAGGCAGTTCGCTTGCCTAAAGCCTTCCGTTTTAATGGTACTGA
GGTCGCCATCAAAAGCTTTGGTCGTGGCGTGTTACTCATGCCCATCGACAATCCTTGGGATATCATGTTAGAAGCCATCA
ATGAGTTTGAGGTGGGATTCCAGTTGGAGCGAGCTGATCAAGGCGAACAGTTCCGTGAGGAATTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References