Detailed information of TA system TA069293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1576027..1576706
• Replicon: chromosome
• Accession: NZ_CP018256
• Organism: Acinetobacter baumannii strain AF-673

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: BS065_RS07525
• Protein ID: WP_000838146.1
• Coordinates: 1576027..1576209 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: BS065_RS07530
• Protein ID: WP_000966688.1
• Coordinates: 1576302..1576706 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS065_RS07480	1571100..1571504	+	405	WP_000247948.1	hypothetical protein	-
BS065_RS07485	1571476..1571844	+	369	WP_002055488.1	hypothetical protein	-
BS065_RS07490	1571846..1572244	+	399	WP_001251850.1	hypothetical protein	-
BS065_RS07495	1572246..1572464	+	219	WP_001277687.1	hypothetical protein	-
BS065_RS07500	1572558..1572911	+	354	WP_000064599.1	hypothetical protein	-
BS065_RS07505	1572911..1574146	+	1236	WP_000002422.1	hypothetical protein	-
BS065_RS07510	1574199..1575116	+	918	WP_000094250.1	hypothetical protein	-
BS065_RS07515	1575186..1575701	+	516	WP_001185608.1	hypothetical protein	-
BS065_RS07525	1576027..1576209	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
BS065_RS07530	1576302..1576706	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BS065_RS07535	1576805..1576981	+	177	WP_014466185.1	hypothetical protein	-
BS065_RS07540	1576990..1577313	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
BS065_RS07545	1577345..1578139	+	795	WP_000720608.1	hypothetical protein	-
BS065_RS07550	1578188..1578427	-	240	WP_000763623.1	Arc family DNA-binding protein	-
BS065_RS07555	1578550..1578705	+	156	WP_001103649.1	Arc family DNA-binding protein	-
BS065_RS07560	1578702..1579694	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1544753..1599992	55239

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T69293 WP_000838146.1 NZ_CP018256:1576027-1576209 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T69293 NZ_CP018256:1576027-1576209 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT69293 WP_000966688.1 NZ_CP018256:1576302-1576706 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT69293 NZ_CP018256:1576302-1576706 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6