Detailed information of TA system TA069289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1713604..1714283
• Replicon: chromosome
• Accession: NZ_CP018254
• Organism: Acinetobacter baumannii strain AF-401

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: BS064_RS08370
• Protein ID: WP_000838146.1
• Coordinates: 1713604..1713786 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BS064_RS08375
• Protein ID: WP_032052307.1
• Coordinates: 1713879..1714283 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS064_RS08330	1708853..1709257	+	405	WP_002047124.1	hypothetical protein	-
BS064_RS08335	1709229..1709597	+	369	WP_031985076.1	hypothetical protein	-
BS064_RS08340	1709599..1709997	+	399	WP_043053690.1	hypothetical protein	-
BS064_RS08345	1710066..1710419	+	354	WP_060513623.1	hypothetical protein	-
BS064_RS08350	1710419..1711723	+	1305	WP_073392614.1	pyocin knob domain-containing protein	-
BS064_RS08355	1711776..1712693	+	918	WP_041172225.1	hypothetical protein	-
BS064_RS08360	1712763..1713278	+	516	WP_017817058.1	hypothetical protein	-
BS064_RS08370	1713604..1713786	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
BS064_RS08375	1713879..1714283	+	405	WP_032052307.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BS064_RS08380	1714383..1715063	+	681	WP_000721572.1	hypothetical protein	-
BS064_RS08385	1715065..1715328	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1684009..1735068	51059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T69289 WP_000838146.1 NZ_CP018254:1713604-1713786 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T69289 NZ_CP018254:1713604-1713786 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14646.75 Da
• Isoelectric Point: 4.5998

>AT69289 WP_032052307.1 NZ_CP018254:1713879-1714283 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPKYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT69289 NZ_CP018254:1713879-1714283 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTAAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7