Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1241657..1242135 Replicon chromosome
Accession NZ_CP018250
Organism Escherichia coli strain 10671

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BFL17_RS06450 Protein ID WP_001303876.1
Coordinates 1241657..1241944 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BFL17_RS06455 Protein ID WP_000536233.1
Coordinates 1241944..1242135 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL17_RS06400 1236806..1239277 - 2472 WP_000034474.1 exonuclease -
BFL17_RS06405 1239371..1239562 - 192 WP_001098307.1 DUF1482 family protein -
BFL17_RS06410 1239559..1239747 - 189 WP_000413705.1 cell division inhibition protein DicB -
BFL17_RS06420 1240321..1240506 + 186 WP_001133046.1 hypothetical protein -
BFL17_RS06425 1240693..1241082 - 390 WP_000394511.1 hypothetical protein -
BFL17_RS06435 1241224..1241379 - 156 WP_000379575.1 DUF1391 family protein -
BFL17_RS06450 1241657..1241944 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL17_RS06455 1241944..1242135 - 192 WP_000536233.1 hypothetical protein Antitoxin
BFL17_RS06460 1242163..1242564 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BFL17_RS06465 1242673..1242945 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BFL17_RS06470 1242929..1243354 + 426 WP_000693855.1 Rha family transcriptional regulator -
BFL17_RS06475 1243561..1244016 - 456 WP_000273724.1 hypothetical protein -
BFL17_RS06480 1244095..1245186 + 1092 WP_001205823.1 hypothetical protein -
BFL17_RS06485 1245193..1245939 + 747 WP_000788751.1 ATP-binding protein -
BFL17_RS06490 1245961..1246731 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T69216 WP_001303876.1 NZ_CP018250:c1241944-1241657 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T69216 NZ_CP018250:c1241944-1241657 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT69216 WP_000536233.1 NZ_CP018250:c1242135-1241944 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT69216 NZ_CP018250:c1242135-1241944 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References