Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1424123..1424918 Replicon chromosome
Accession NZ_CP018247
Organism Escherichia coli strain 7784

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag BFL18_RS07550 Protein ID WP_000854914.1
Coordinates 1424544..1424918 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BFL18_RS07545 Protein ID WP_001416641.1
Coordinates 1424123..1424497 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL18_RS07500 1419478..1420383 + 906 WP_000203541.1 chemotaxis protein -
BFL18_RS07505 1420380..1421450 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
BFL18_RS07520 1421790..1422608 + 819 WP_001234682.1 DUF945 domain-containing protein -
BFL18_RS07525 1422699..1423184 + 486 WP_000214398.1 antirestriction protein -
BFL18_RS07530 1423200..1423676 + 477 WP_001415969.1 RadC family protein -
BFL18_RS07535 1423739..1423960 + 222 WP_001220314.1 DUF987 domain-containing protein -
BFL18_RS07545 1424123..1424497 + 375 WP_001416641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BFL18_RS07550 1424544..1424918 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
BFL18_RS07555 1424915..1425406 + 492 WP_000976853.1 hypothetical protein -
BFL18_RS07560 1425418..1425615 + 198 WP_000839282.1 DUF957 domain-containing protein -
BFL18_RS07565 1425700..1426542 + 843 WP_001280481.1 DUF4942 domain-containing protein -
BFL18_RS07575 1427013..1427951 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
BFL18_RS07580 1428006..1428743 + 738 WP_000283664.1 zinc-binding phosphatase -
BFL18_RS07585 1428767..1429321 + 555 WP_001001917.1 molecular chaperone YcdY -
BFL18_RS07590 1429423..1429914 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - iroB / csgG / csgF / csgE / csgD / csgB / csgA / csgC 1393396..1435482 42086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T69177 WP_000854914.1 NZ_CP018247:1424544-1424918 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T69177 NZ_CP018247:1424544-1424918 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13778.61 Da        Isoelectric Point: 6.6249

>AT69177 WP_001416641.1 NZ_CP018247:1424123-1424497 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGFCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT69177 NZ_CP018247:1424123-1424497 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTTCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5


Antitoxin

Source ID Structure

References