Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1183465..1183943 Replicon chromosome
Accession NZ_CP018245
Organism Escherichia coli strain 472

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BFL23_RS06030 Protein ID WP_001303876.1
Coordinates 1183465..1183752 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BFL23_RS06035 Protein ID WP_000536233.1
Coordinates 1183752..1183943 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL23_RS05980 1178614..1181085 - 2472 WP_000034474.1 exonuclease -
BFL23_RS05985 1181179..1181370 - 192 WP_001098307.1 DUF1482 family protein -
BFL23_RS05990 1181367..1181555 - 189 WP_000413705.1 cell division inhibition protein DicB -
BFL23_RS06000 1182129..1182314 + 186 WP_001133046.1 hypothetical protein -
BFL23_RS06005 1182501..1182890 - 390 WP_000394511.1 hypothetical protein -
BFL23_RS06015 1183032..1183187 - 156 WP_000379575.1 DUF1391 family protein -
BFL23_RS06030 1183465..1183752 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL23_RS06035 1183752..1183943 - 192 WP_000536233.1 hypothetical protein Antitoxin
BFL23_RS06040 1183971..1184372 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BFL23_RS06045 1184481..1184753 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BFL23_RS06050 1184737..1185162 + 426 WP_000693855.1 Rha family transcriptional regulator -
BFL23_RS06055 1185369..1185824 - 456 WP_000273724.1 hypothetical protein -
BFL23_RS06060 1185903..1186994 + 1092 WP_001205823.1 hypothetical protein -
BFL23_RS06065 1187001..1187747 + 747 WP_000788751.1 ATP-binding protein -
BFL23_RS06070 1187769..1188539 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T69143 WP_001303876.1 NZ_CP018245:c1183752-1183465 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T69143 NZ_CP018245:c1183752-1183465 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT69143 WP_000536233.1 NZ_CP018245:c1183943-1183752 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT69143 NZ_CP018245:c1183943-1183752 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References