Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1233793..1234271 Replicon chromosome
Accession NZ_CP018243
Organism Escherichia coli strain 350

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BFL21_RS06215 Protein ID WP_001303876.1
Coordinates 1233793..1234080 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BFL21_RS06220 Protein ID WP_000536233.1
Coordinates 1234080..1234271 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL21_RS06165 1228942..1231413 - 2472 WP_000034474.1 exonuclease -
BFL21_RS06170 1231507..1231698 - 192 WP_001098307.1 DUF1482 family protein -
BFL21_RS06175 1231695..1231883 - 189 WP_000413705.1 cell division inhibition protein DicB -
BFL21_RS06185 1232457..1232642 + 186 WP_001133046.1 hypothetical protein -
BFL21_RS06190 1232829..1233218 - 390 WP_000394511.1 hypothetical protein -
BFL21_RS06200 1233360..1233515 - 156 WP_000379575.1 DUF1391 family protein -
BFL21_RS06215 1233793..1234080 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL21_RS06220 1234080..1234271 - 192 WP_000536233.1 hypothetical protein Antitoxin
BFL21_RS06225 1234299..1234700 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BFL21_RS06230 1234809..1235081 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BFL21_RS06235 1235065..1235490 + 426 WP_000693855.1 Rha family transcriptional regulator -
BFL21_RS06240 1235697..1236152 - 456 WP_000273724.1 hypothetical protein -
BFL21_RS06245 1236231..1237322 + 1092 WP_001205823.1 hypothetical protein -
BFL21_RS06250 1237329..1238075 + 747 WP_000788751.1 ATP-binding protein -
BFL21_RS06255 1238097..1238867 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T69102 WP_001303876.1 NZ_CP018243:c1234080-1233793 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T69102 NZ_CP018243:c1234080-1233793 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT69102 WP_000536233.1 NZ_CP018243:c1234271-1234080 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT69102 NZ_CP018243:c1234271-1234080 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References