Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1397877..1398672 Replicon chromosome
Accession NZ_CP018239
Organism Escherichia coli strain 272

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag BFL22_RS07365 Protein ID WP_000854914.1
Coordinates 1398298..1398672 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag BFL22_RS07360 Protein ID WP_001280954.1
Coordinates 1397877..1398251 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL22_RS07315 1393232..1394137 + 906 WP_000203541.1 chemotaxis protein -
BFL22_RS07320 1394134..1395204 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
BFL22_RS07335 1395544..1396362 + 819 WP_001234682.1 DUF945 domain-containing protein -
BFL22_RS07340 1396453..1396938 + 486 WP_000214398.1 antirestriction protein -
BFL22_RS07345 1396954..1397430 + 477 WP_001186738.1 RadC family protein -
BFL22_RS07350 1397493..1397714 + 222 WP_001220314.1 DUF987 domain-containing protein -
BFL22_RS07360 1397877..1398251 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BFL22_RS07365 1398298..1398672 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
BFL22_RS07370 1398669..1399160 + 492 WP_000976853.1 hypothetical protein -
BFL22_RS07375 1399172..1399369 + 198 WP_000839282.1 DUF957 domain-containing protein -
BFL22_RS07380 1399454..1400296 + 843 WP_001280481.1 DUF4942 domain-containing protein -
BFL22_RS07390 1400767..1401705 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
BFL22_RS07395 1401760..1402497 + 738 WP_000283664.1 zinc-binding phosphatase -
BFL22_RS07400 1402521..1403075 + 555 WP_001001917.1 molecular chaperone YcdY -
BFL22_RS07405 1403177..1403668 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T69019 WP_000854914.1 NZ_CP018239:1398298-1398672 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T69019 NZ_CP018239:1398298-1398672 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT69019 WP_001280954.1 NZ_CP018239:1397877-1398251 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT69019 NZ_CP018239:1397877-1398251 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References