Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1171002..1171480 Replicon chromosome
Accession NZ_CP018237
Organism Escherichia coli strain 155

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag BFL20_RS05920 Protein ID WP_001303876.1
Coordinates 1171002..1171289 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag BFL20_RS05925 Protein ID WP_000536233.1
Coordinates 1171289..1171480 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL20_RS05870 1166151..1168622 - 2472 WP_000034474.1 exonuclease -
BFL20_RS05875 1168716..1168907 - 192 WP_001098307.1 DUF1482 family protein -
BFL20_RS05880 1168904..1169092 - 189 WP_000413705.1 cell division inhibition protein DicB -
BFL20_RS05890 1169666..1169851 + 186 WP_001133046.1 hypothetical protein -
BFL20_RS05895 1170038..1170427 - 390 WP_000394511.1 hypothetical protein -
BFL20_RS05905 1170569..1170724 - 156 WP_000379575.1 DUF1391 family protein -
BFL20_RS05920 1171002..1171289 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL20_RS05925 1171289..1171480 - 192 WP_000536233.1 hypothetical protein Antitoxin
BFL20_RS05930 1171508..1171909 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
BFL20_RS05935 1172018..1172290 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
BFL20_RS05940 1172274..1172699 + 426 WP_000693855.1 Rha family transcriptional regulator -
BFL20_RS05945 1172906..1173361 - 456 WP_000273724.1 hypothetical protein -
BFL20_RS05950 1173440..1174531 + 1092 WP_001205823.1 hypothetical protein -
BFL20_RS05955 1174538..1175284 + 747 WP_000788751.1 ATP-binding protein -
BFL20_RS05960 1175306..1176076 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T68973 WP_001303876.1 NZ_CP018237:c1171289-1171002 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T68973 NZ_CP018237:c1171289-1171002 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT68973 WP_000536233.1 NZ_CP018237:c1171480-1171289 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT68973 NZ_CP018237:c1171480-1171289 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References