68953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 20564..21261 Replicon plasmid pHSL3
Accession NZ_CP018224
Organism Tardibacter chloracetimidivorans strain JJ-A5

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag BSL82_RS18675 Protein ID WP_013041565.1
Coordinates 20887..21261 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag BSL82_RS18670 Protein ID WP_006964370.1
Coordinates 20564..20890 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSL82_RS18640 16161..16916 + 756 WP_022675885.1 P-type conjugative transfer protein TrbJ -
BSL82_RS18645 16926..17168 + 243 WP_019053956.1 EexN family lipoprotein -
BSL82_RS18650 17179..18894 + 1716 WP_026149856.1 P-type conjugative transfer protein TrbL -
BSL82_RS18655 18897..20009 + 1113 WP_013041568.1 muramidase -
BSL82_RS18660 20030..20329 - 300 WP_013041567.1 hypothetical protein -
BSL82_RS18665 20322..20564 - 243 WP_013041566.1 hypothetical protein -
BSL82_RS18670 20564..20890 - 327 WP_006964370.1 helix-turn-helix domain-containing protein Antitoxin
BSL82_RS18675 20887..21261 - 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSL82_RS18685 21808..22830 + 1023 WP_048575010.1 IS1595 family transposase -
BSL82_RS18695 23426..24316 - 891 Protein_30 IS110 family transposase -
BSL82_RS18700 24380..25246 - 867 WP_006961816.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..63065 63065
- flank IS/Tn - - 21808..22830 1022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T68953 WP_013041565.1 NZ_CP018224:c21261-20887 [Tardibacter chloracetimidivorans]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

>T68953 NZ_CP018224:c21261-20887 [Tardibacter chloracetimidivorans]
ATGGATACGGAACGGCCGGTTCGATGGGTGGCATCGTCAAAGCGCGATTTTCGGGAGTTCCCGGACGATGTGCAGGACGT
AATGGGCTATGCCCTGCACCTTGCGCAGCAAGGCGGGCAGCACGCCAGCACTAAGCCGTTGAAGGGCTTTGGCGGCGCTG
GCGTGGTCGAGATCATAGACGACCACCAAGGCGATACGTTCCGCACGGTCTATACGGTCAAATTCGCGGAGGCGGTCTAT
GTCCTGCACGCCTTCCAGAAGAAATCCAAGCAGGGCAAGGCCACGCCGCAGGCCGATATGGATTTGATCCGAACGCGGCT
GAAATCCGCCGAGGAGCATCACCGGCAACACCAGACCCCGCGAGGCACAGCATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT68953 WP_006964370.1 NZ_CP018224:c20890-20564 [Tardibacter chloracetimidivorans]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp

>AT68953 NZ_CP018224:c20890-20564 [Tardibacter chloracetimidivorans]
ATGAGCGCACAGGACGAAATCATTGAGGAAGGCAGCGGCAATGTCTTTGCCGATCTAGGCTTTGCCGACCCCGACACCCA
CCTTTTGAAAGCCCAGCTCGTTACCCGTGTGGCCGAGGCCATGCAGGAGCGGAAGTTGACGCAGATCGCCGCCGCCAAGG
TTACGGGATCTACCCAACCGGAATTGTCGCGCATCCTGCGAGGCCAGTTCCGCAGCGTCTCGGTTGAGCGGCTTCTAGCC
ATGCTCACCCGGCTTGGCTGCAAGGTCGATATTGTCGTGCGCCCGCAGGGGCGGACCACTGAATCGGCCGTGATCCACTT
CGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References