Detailed information of TA system TA068950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 149910..150435
• Replicon: plasmid pUO-STmRV1
• Accession: NZ_CP018220
• Organism: Salmonella enterica subsp. enterica strain LSP 389/97

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: A5895_RS26405
• Protein ID: WP_001159863.1
• Coordinates: 149910..150215 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: A5895_RS26410
• Protein ID: WP_000813641.1
• Coordinates: 150217..150435 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5895_RS26365	145289..145849	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
A5895_RS26865	146005..146292	+	288	WP_071530243.1	hypothetical protein	-
A5895_RS26370	146569..147054	-	486	WP_000905606.1	membrane protein	-
A5895_RS26375	147048..147557	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
A5895_RS26385	147561..148274	-	714	Protein_178	EAL domain-containing protein	-
A5895_RS26390	148283..149065	-	783	WP_000082169.1	site-specific integrase	-
A5895_RS26395	149100..149621	-	522	WP_000198608.1	hypothetical protein	-
A5895_RS26400	149618..149908	-	291	WP_001266176.1	hypothetical protein	-
A5895_RS26405	149910..150215	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
A5895_RS26410	150217..150435	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
A5895_RS26415	151111..151632	+	522	WP_010999942.1	hypothetical protein	-
A5895_RS26425	152116..152412	+	297	WP_001687482.1	hypothetical protein	-
A5895_RS26430	152805..153509	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
A5895_RS26435	153515..153673	+	159	WP_080223426.1	DUF3330 domain-containing protein	-
A5895_RS26440	153849..154409	+	561	WP_001161490.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..197365	197365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T68950 WP_001159863.1 NZ_CP018220:c150215-149910 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T68950 NZ_CP018220:c150215-149910 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT68950 WP_000813641.1 NZ_CP018220:c150435-150217 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT68950 NZ_CP018220:c150435-150217 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6