Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 801982..802459 Replicon chromosome
Accession NZ_CP018205
Organism Staphylococcus aureus strain HG001 isolate RN1

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag BSR30_RS04035 Protein ID WP_000052078.1
Coordinates 801982..802170 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag BSR30_RS04040 Protein ID WP_001059690.1
Coordinates 802199..802459 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR30_RS04005 798023..798493 + 471 WP_000824472.1 hypothetical protein -
BSR30_RS04010 798834..799520 + 687 WP_001548082.1 thermonuclease family protein -
BSR30_RS04015 799877..800077 + 201 WP_001059082.1 cold-shock protein -
BSR30_RS04020 800573..800791 - 219 WP_000005886.1 hypothetical protein -
BSR30_RS04025 800853..801137 - 285 WP_001004395.1 hypothetical protein -
BSR30_RS04030 801225..801794 - 570 WP_001106654.1 hypothetical protein -
BSR30_RS04035 801982..802170 - 189 WP_000052078.1 hypothetical protein Toxin
BSR30_RS04040 802199..802459 - 261 WP_001059690.1 hypothetical protein Antitoxin
BSR30_RS04045 802800..803003 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
BSR30_RS04050 803000..803236 - 237 WP_000368687.1 hypothetical protein -
BSR30_RS04055 803461..804042 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
BSR30_RS04060 804115..804732 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
BSR30_RS04065 804887..805381 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
BSR30_RS04070 805780..806202 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
BSR30_RS04075 806350..807066 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T68897 WP_000052078.1 NZ_CP018205:c802170-801982 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T68897 NZ_CP018205:c802170-801982 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT68897 WP_001059690.1 NZ_CP018205:c802459-802199 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT68897 NZ_CP018205:c802459-802199 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References