Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1876173..1876792 Replicon chromosome
Accession NZ_CP018202
Organism Pseudomonas syringae pv. actinidiae ICMP 9853

Toxin (Protein)


Gene name tad Uniprot ID A0A2G9L4Q9
Locus tag JN853_RS09325 Protein ID WP_004397564.1
Coordinates 1876173..1876475 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0K8LSV9
Locus tag JN853_RS09330 Protein ID WP_004397562.1
Coordinates 1876472..1876792 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN853_RS09300 1871948..1872640 - 693 WP_004397574.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -
JN853_RS09305 1872654..1873115 - 462 WP_004397572.1 DUF1456 family protein -
JN853_RS09310 1873197..1873907 - 711 WP_004397570.1 rRNA pseudouridine synthase -
JN853_RS09315 1874001..1874441 - 441 WP_004397568.1 GNAT family N-acetyltransferase -
JN853_RS09320 1874543..1875886 - 1344 WP_004397566.1 30S ribosomal protein S12 methylthiotransferase RimO -
JN853_RS09325 1876173..1876475 + 303 WP_004397564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN853_RS09330 1876472..1876792 + 321 WP_004397562.1 helix-turn-helix domain-containing protein Antitoxin
JN853_RS09335 1876894..1877982 - 1089 WP_004397558.1 catalase family protein -
JN853_RS09345 1878304..1880199 + 1896 WP_004397556.1 potassium transporter Kup -
JN853_RS09350 1880294..1881628 - 1335 WP_004397555.1 virulence factor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-89)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11152.69 Da        Isoelectric Point: 8.0629

>T68893 WP_004397564.1 NZ_CP018202:1876173-1876475 [Pseudomonas syringae pv. actinidiae ICMP 9853]
MPDEVQDVFGFALSLAQEGSKHSQAKPMKGFSGAGVLEVVEDYDSDTYRAVYSVKFDAMVYVLHCFQKKSTSGIKTAKHD
IELIKSRLKAVQAHVESNRR

Download         Length: 303 bp

>T68893 NZ_CP018202:1876173-1876475 [Pseudomonas syringae pv. actinidiae ICMP 9853]
ATGCCTGACGAGGTGCAGGATGTATTTGGATTCGCCCTGAGTCTCGCGCAGGAAGGCTCCAAACACTCTCAAGCCAAACC
GATGAAGGGTTTCTCCGGAGCAGGGGTGTTGGAGGTCGTTGAGGACTATGATAGTGACACCTATCGCGCTGTATATTCCG
TGAAATTCGATGCAATGGTCTACGTTCTGCACTGTTTTCAGAAAAAGTCGACCTCGGGCATTAAAACGGCAAAACATGAT
ATTGAATTGATCAAATCACGACTCAAAGCCGTACAAGCACATGTAGAGAGTAATAGACGATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11639.62 Da        Isoelectric Point: 10.2027

>AT68893 WP_004397562.1 NZ_CP018202:1876472-1876792 [Pseudomonas syringae pv. actinidiae ICMP 9853]
MIDIEEGSGNVYADLGRADANEMSIKAQLASKIGTIIKARHLTQLQAAEILAMPQPKVSEMLRGKFRGISEAKMMDCLSR
LGRDVQIVVKAAPRSRREGRVEVVFA

Download         Length: 321 bp

>AT68893 NZ_CP018202:1876472-1876792 [Pseudomonas syringae pv. actinidiae ICMP 9853]
ATGATTGATATCGAAGAAGGTAGCGGCAACGTTTACGCTGATCTTGGGCGAGCTGATGCGAACGAAATGTCAATCAAGGC
TCAATTAGCCTCAAAAATCGGCACAATCATCAAGGCTCGACACCTGACCCAGCTCCAGGCGGCTGAGATACTGGCAATGC
CTCAGCCAAAGGTTTCAGAGATGCTTAGGGGCAAGTTCAGAGGCATAAGCGAGGCCAAAATGATGGACTGCCTTTCGCGT
CTCGGACGTGACGTGCAGATTGTGGTCAAGGCAGCACCTCGTTCTCGGCGAGAGGGGCGAGTTGAAGTTGTATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G9L4Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LSV9

References