Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1243257..1243798 Replicon chromosome
Accession NZ_CP018202
Organism Pseudomonas syringae pv. actinidiae ICMP 9853

Toxin (Protein)


Gene name relE Uniprot ID A0A2V0Q684
Locus tag JN853_RS06270 Protein ID WP_003382250.1
Coordinates 1243257..1243532 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K8LU58
Locus tag JN853_RS06275 Protein ID WP_003382249.1
Coordinates 1243532..1243798 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN853_RS06245 1238388..1239413 - 1026 WP_003380375.1 TRAP transporter substrate-binding protein -
JN853_RS06250 1239470..1240354 - 885 WP_003380378.1 SMP-30/gluconolactonase/LRE family protein -
JN853_RS06255 1240414..1241238 - 825 WP_003380380.1 NAD(P)-dependent oxidoreductase -
JN853_RS06260 1241417..1242685 - 1269 WP_017698468.1 OprD family porin -
JN853_RS06270 1243257..1243532 - 276 WP_003382250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN853_RS06275 1243532..1243798 - 267 WP_003382249.1 ribbon-helix-helix domain-containing protein Antitoxin
JN853_RS06280 1243963..1245885 - 1923 WP_017698469.1 methyl-accepting chemotaxis protein -
JN853_RS06285 1246244..1248124 + 1881 WP_003382247.1 methyl-accepting chemotaxis protein -
JN853_RS06290 1248252..1248482 - 231 WP_017698470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1233856..1243798 9942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10720.38 Da        Isoelectric Point: 7.0123

>T68892 WP_003382250.1 NZ_CP018202:c1243532-1243257 [Pseudomonas syringae pv. actinidiae ICMP 9853]
MELMWTSKALSDVARLYDFLAVANQPAAAQTVQKLTAAPIILLSNPRIGERLEEFEPRDVRRIQIGRYEMRYEIVDSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T68892 NZ_CP018202:c1243532-1243257 [Pseudomonas syringae pv. actinidiae ICMP 9853]
ATGGAGCTGATGTGGACAAGCAAAGCGCTATCTGACGTCGCCCGCCTGTATGATTTTTTAGCGGTAGCAAACCAGCCCGC
TGCCGCCCAGACCGTACAGAAGCTTACAGCGGCGCCGATCATACTCCTTTCCAACCCGCGGATTGGTGAGCGTCTGGAGG
AGTTTGAGCCCCGGGATGTGCGCAGAATTCAGATAGGCCGCTATGAAATGCGCTACGAAATTGTGGACTCAACAATTTAT
CTGTTGCGGCTGTGGCATACACGCGAGGATCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9934.24 Da        Isoelectric Point: 5.7066

>AT68892 WP_003382249.1 NZ_CP018202:c1243798-1243532 [Pseudomonas syringae pv. actinidiae ICMP 9853]
MTTKTRSVTAHIPEQLAEKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSLST
ATPLPVPR

Download         Length: 267 bp

>AT68892 NZ_CP018202:c1243798-1243532 [Pseudomonas syringae pv. actinidiae ICMP 9853]
ATGACAACCAAGACCCGATCTGTAACAGCTCACATACCCGAACAATTGGCTGAAAAAGTCGACCTGATGGCAGAGCGACT
CGAACGCTCTAAAAACTGGATCGTCAAACAGGCCTTGTCTGCATGGATAGATCAGGAGGAAGAACGTAGTCGCCTCACTC
GCGAAGCATTAGCCGATGTCGATGCTGGCCGTGTGATTGACCATCAGGCTGTTCAGGCCTGGGCTGACAGTTTAAGCACC
GCTACGCCTCTGCCGGTTCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V0Q684

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LU58

References