Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 80038..80567 Replicon chromosome
Accession NZ_CP018199
Organism Staphylococcus succinus strain 14BME20

Toxin (Protein)


Gene name mazF Uniprot ID A0A1S2MGJ9
Locus tag BK815_RS00420 Protein ID WP_046837772.1
Coordinates 80205..80567 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S2MIN4
Locus tag BK815_RS00415 Protein ID WP_046837773.1
Coordinates 80038..80208 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK815_RS00390 75808..76287 + 480 WP_073504045.1 PH domain-containing protein -
BK815_RS00395 76280..77782 + 1503 WP_073504046.1 PH domain-containing protein -
BK815_RS00400 77775..78281 + 507 WP_073504047.1 PH domain-containing protein -
BK815_RS00405 78336..78686 + 351 WP_073504048.1 holo-ACP synthase -
BK815_RS00410 78802..79950 + 1149 WP_073504049.1 alanine racemase -
BK815_RS00415 80038..80208 + 171 WP_046837773.1 hypothetical protein Antitoxin
BK815_RS00420 80205..80567 + 363 WP_046837772.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BK815_RS00425 80917..81918 + 1002 WP_046837771.1 PP2C family protein-serine/threonine phosphatase -
BK815_RS00430 81998..82324 + 327 WP_046837770.1 anti-sigma factor antagonist -
BK815_RS00435 82326..82808 + 483 WP_069822703.1 anti-sigma B factor RsbW -
BK815_RS00440 82783..83553 + 771 WP_073504050.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13476.56 Da        Isoelectric Point: 10.0960

>T68886 WP_046837772.1 NZ_CP018199:80205-80567 [Staphylococcus succinus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDDKMREVNNAIDISLGLHSVRTNKS

Download         Length: 363 bp

>T68886 NZ_CP018199:80205-80567 [Staphylococcus succinus]
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTGCAAGGGTCTGAGCAAGGGGGAATTAGACCTGTCGT
GATTATACAAAACGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCAGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCAACACATGTAGAAATAGAAAAAAGTAAGTATAAGCTAGATAAAGATTCTGTTATTTTGTTAGAACAAATTAGA
ACTTTAGATAAAAACAGACTGAAAGAAAAATTAACTTATCTCTCTGATGATAAAATGAGAGAAGTAAACAATGCTATTGA
CATAAGCTTAGGATTACATAGTGTTAGGACAAACAAATCCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6320.97 Da        Isoelectric Point: 4.0121

>AT68886 WP_046837773.1 NZ_CP018199:80038-80208 [Staphylococcus succinus]
MVSFTQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT68886 NZ_CP018199:80038-80208 [Staphylococcus succinus]
ATGGTAAGTTTTACTCAAAGCAGAAATCACAGTATTGAACAATTACTAAAAGAAGGCTATTCTCAAATGGCCGACTTAAA
CCTCTCCCTTGCAGCGGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAACGAAGTCTACATCAGCTCTAAGAATA
ACAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2MGJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2MIN4

References