Detailed information of TA system TA068884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1881390..1881856
• Replicon: chromosome
• Accession: NZ_CP018196
• Organism: Fusobacterium necrophorum subsp. funduliforme strain F1291

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BSQ88_RS08855
• Protein ID: WP_005956979.1
• Coordinates: 1881617..1881856 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J5W0H3
• Locus tag: BSQ88_RS08850
• Protein ID: WP_005955951.1
• Coordinates: 1881390..1881620 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSQ88_RS08825	1876632..1876943	-	312	WP_005955931.1	50S ribosomal protein L21	-
BSQ88_RS08830	1877068..1878735	-	1668	WP_005956956.1	tetratricopeptide repeat protein	-
BSQ88_RS08835	1878778..1879254	-	477	WP_005955939.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
BSQ88_RS08840	1879270..1880244	-	975	WP_005956947.1	D-glycero-beta-D-manno-heptose-7-phosphate kinase	-
BSQ88_RS08845	1880370..1880888	-	519	WP_005957007.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
BSQ88_RS08850	1881390..1881620	+	231	WP_005955951.1	hypothetical protein	Antitoxin
BSQ88_RS08855	1881617..1881856	+	240	WP_005956979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSQ88_RS08860	1882209..1882481	-	273	WP_009006013.1	hypothetical protein	-
BSQ88_RS08865	1882481..1882873	-	393	WP_005960422.1	hypothetical protein	-
BSQ88_RS08870	1882998..1883576	-	579	WP_062687120.1	N-acetylmuramoyl-L-alanine amidase	-
BSQ88_RS08875	1883630..1884511	-	882	Protein_1721	hypothetical protein	-
BSQ88_RS08880	1884515..1884766	-	252	WP_123539860.1	hypothetical protein	-
BSQ88_RS08885	1884763..1885422	-	660	WP_123539861.1	hypothetical protein	-
BSQ88_RS08890	1885432..1886241	-	810	WP_062624693.1	radical SAM protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-76)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9524.31 Da
• Isoelectric Point: 10.2227

>T68884 WP_005956979.1 NZ_CP018196:1881617-1881856 [Fusobacterium necrophorum subsp. funduliforme]
MKYRMEFSQQGKKELKKLDAFTQKIIMKWICKNLIDTENPRIHGKELKGNLKCFWRYRVGNYRLLADIQDETVTILLMT

Nucleotide

• Length: 240 bp

>T68884 NZ_CP018196:1881617-1881856 [Fusobacterium necrophorum subsp. funduliforme]
ATGAAATACCGAATGGAATTTTCACAACAAGGAAAAAAGGAATTGAAAAAATTAGATGCCTTTACTCAAAAAATTATTAT
GAAGTGGATCTGTAAAAATCTAATTGATACGGAAAATCCAAGAATACATGGAAAAGAACTAAAGGGAAACTTAAAGTGTT
TTTGGCGTTATCGTGTCGGAAATTACAGGTTATTAGCCGATATTCAAGACGAAACGGTAACCATTTTATTAATGACATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9012.25 Da
• Isoelectric Point: 4.3363

>AT68884 WP_005955951.1 NZ_CP018196:1881390-1881620 [Fusobacterium necrophorum subsp. funduliforme]
MSIISLRLNEKEEKLLREFSAFEGLGISSYIKKIIYERLEDEYDIKCFDKAYQEYLESGKKSYSFDEVLNELGIEL

Nucleotide

• Length: 231 bp

>AT68884 NZ_CP018196:1881390-1881620 [Fusobacterium necrophorum subsp. funduliforme]
ATGTCTATTATTTCTTTACGACTAAATGAAAAAGAAGAAAAATTATTAAGAGAATTCTCAGCATTTGAGGGCTTGGGAAT
CTCCTCATATATCAAAAAAATTATCTATGAAAGATTAGAGGATGAATATGATATTAAATGTTTTGATAAAGCATATCAGG
AATATCTGGAAAGTGGAAAAAAATCATATTCTTTTGATGAAGTTTTAAATGAATTGGGAATTGAGCTATGA

Structures

Antitoxin

• AlphaFold DB: J5W0H3