Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 31171..32405 Replicon plasmid unnamed
Accession NZ_CP018188
Organism Streptococcus salivarius strain ICDC2

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag BSR19_RS10680 Protein ID WP_156247118.1
Coordinates 31171..31929 (-) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag BSR19_RS10685 Protein ID WP_049553660.1
Coordinates 31929..32405 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR19_RS10665 26288..27529 + 1242 WP_050088028.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
BSR19_RS10670 27513..29792 - 2280 WP_156247116.1 ATP-binding protein -
BSR19_RS10675 29884..30780 + 897 WP_156247117.1 tyrosine-type recombinase/integrase -
BSR19_RS10680 31171..31929 - 759 WP_156247118.1 zeta toxin family protein Toxin
BSR19_RS10685 31929..32405 - 477 WP_049553660.1 helix-turn-helix domain-containing protein Antitoxin
BSR19_RS10690 32475..32747 - 273 WP_156247119.1 hypothetical protein -
BSR19_RS10695 32774..33311 - 538 Protein_36 hypothetical protein -
BSR19_RS10700 33324..33704 - 381 WP_070839262.1 hypothetical protein -
BSR19_RS10705 33697..34020 - 324 WP_197092268.1 hypothetical protein -
BSR19_RS10710 35358..36542 + 1185 Protein_39 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188293 188293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28819.67 Da        Isoelectric Point: 6.5919

>T68879 WP_156247118.1 NZ_CP018188:c31929-31171 [Streptococcus salivarius]
MEIQDYTGREFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDLIVNNLVENTHQLEQLGIFEQIQIYQRDRTCVYDSRDDEISAAAVLHELLFGEWSQVEKDML
KSGEERFKDLTN

Download         Length: 759 bp

>T68879 NZ_CP018188:c31929-31171 [Streptococcus salivarius]
ATGGAAATCCAAGATTATACTGGTAGAGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCTCTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAAGATTTTGCAGGCAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGACGTTCCAAAGGAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATCTGATAGTGAACAATCTAGTTGAGAA
TACCCACCAGCTGGAGCAATTAGGTATCTTTGAACAAATCCAAATCTATCAACGAGATAGGACCTGTGTTTACGATTCGA
GAGATGATGAAATATCAGCAGCAGCTGTTCTTCATGAATTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGATATGCTT
AAATCTGGAGAAGAAAGATTTAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18186.66 Da        Isoelectric Point: 4.5516

>AT68879 WP_049553660.1 NZ_CP018188:c32405-31929 [Streptococcus salivarius]
MIGKNIKSLRKTHGLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSNDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT68879 NZ_CP018188:c32405-31929 [Streptococcus salivarius]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGGCTTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTAAGCCGTTATGAAAATGGAACTAGTTCAGTATCTACAGAACTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTACTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTAATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References