Detailed information of TA system TA068878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1420280..1420739
• Replicon: chromosome
• Accession: NZ_CP018187
• Organism: Streptococcus salivarius strain ICDC2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BSR19_RS06945
• Protein ID: WP_156246878.1
• Coordinates: 1420280..1420534 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F8LI53
• Locus tag: BSR19_RS06950
• Protein ID: WP_013990356.1
• Coordinates: 1420524..1420739 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR19_RS06915	1415469..1416224	+	756	WP_156246874.1	hypothetical protein	-
BSR19_RS06920	1416276..1416857	-	582	WP_064525292.1	DUF4352 domain-containing protein	-
BSR19_RS06925	1417004..1417879	-	876	WP_156246875.1	HAMP domain-containing histidine kinase	-
BSR19_RS06930	1417879..1418562	-	684	WP_118172357.1	response regulator transcription factor	-
BSR19_RS06935	1418726..1419358	-	633	WP_156246876.1	nitroreductase family protein	-
BSR19_RS06940	1419449..1420135	-	687	WP_156246877.1	DUF1275 domain-containing protein	-
BSR19_RS06945	1420280..1420534	-	255	WP_156246878.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSR19_RS06950	1420524..1420739	-	216	WP_013990356.1	hypothetical protein	Antitoxin
BSR19_RS06955	1420871..1421713	-	843	WP_156246879.1	aldo/keto reductase	-
BSR19_RS06960	1421847..1422848	-	1002	WP_148512587.1	UDP-glucose 4-epimerase GalE	-
BSR19_RS06965	1422978..1424588	-	1611	WP_156246880.1	alpha-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9863.59 Da
• Isoelectric Point: 10.9651

>T68878 WP_156246878.1 NZ_CP018187:c1420534-1420280 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRVTDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDDELIILALEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T68878 NZ_CP018187:c1420534-1420280 [Streptococcus salivarius]
ATGACCTATAAGATAGTACCAACCCCTAAATTTGCCAAAAGTTTTAAAAAGTTGGACCCTTTTGTCAGGAAACAAATTAA
GTCTTATCTCAATCGTGTCACAGATAATCCAAGAGCTAAGGGTAAGGCCTTAGTTGCCAATCGAACTGGACAATGGCGCT
ATCGTATTGGTGCCTATCGTGTTATTGTCAATATTCAGGACGATGAACTAATCATACTTGCCCTCGAAGTTGGTCATAGA
CGTGATATCTATTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8016.98 Da
• Isoelectric Point: 3.8852

>AT68878 WP_013990356.1 NZ_CP018187:c1420739-1420524 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Nucleotide

• Length: 216 bp

>AT68878 NZ_CP018187:c1420739-1420524 [Streptococcus salivarius]
ATGACAACAATTACATTGAAGGTTTCAGAAGCAGATAAGAAGTTCATGCAGGCAATTGCGAAATTTGAAGGCGTATCTTT
GTCAGAATTAATTCGTACCAAGACTTTAGACGCCATTGAGGATGAATACGATGCTAGAGTAGCCGATTTGGCATTAGCAG
AATATGAAGACTATCTTGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: F8LI53