Detailed information of TA system TA068876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 44028..44628
• Replicon: chromosome
• Accession: NZ_CP018187
• Organism: Streptococcus salivarius strain ICDC2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: J7T5K5
• Locus tag: BSR19_RS00270
• Protein ID: WP_002889576.1
• Coordinates: 44299..44628 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F8LGC9
• Locus tag: BSR19_RS00265
• Protein ID: WP_002889575.1
• Coordinates: 44028..44315 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR19_RS00250	39476..42175	+	2700	WP_156246285.1	RNA-directed DNA polymerase	-
BSR19_RS00255	42177..42941	+	765	WP_156246286.1	hypothetical protein	-
BSR19_RS00260	43081..43920	-	840	WP_156246287.1	CHAP domain-containing protein	-
BSR19_RS00265	44028..44315	+	288	WP_002889575.1	hypothetical protein	Antitoxin
BSR19_RS00270	44299..44628	+	330	WP_002889576.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSR19_RS00275	44900..46162	+	1263	WP_156246288.1	phosphoribosylamine--glycine ligase	-
BSR19_RS00280	46458..46949	+	492	WP_060972882.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BSR19_RS00285	46936..48027	+	1092	WP_156246289.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BSR19_RS00290	48028..48978	+	951	WP_060972884.1	NAD(P)-binding domain-containing protein	-
BSR19_RS00295	48987..49214	+	228	WP_060972885.1	phosphoribosylaminoimidazole carboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	35297..50693	15396

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12652.60 Da
• Isoelectric Point: 10.2062

>T68876 WP_002889576.1 NZ_CP018187:44299-44628 [Streptococcus salivarius]
MNTTYSLSLTKRARSSLRSIYDYIRDVLSNETAAKKIVSKLLQGMESLKTFPEAGFNADQRYGKRINDTFETRALVVKRY
VILYFIDESRKEIVVSHIFSSKSDYIKLL

Nucleotide

• Length: 330 bp

>T68876 NZ_CP018187:44299-44628 [Streptococcus salivarius]
ATGAATACAACCTATAGTCTTTCACTCACTAAGCGTGCTCGCTCTTCTTTGAGAAGTATATATGACTACATTCGTGATGT
ACTTTCTAATGAAACTGCTGCCAAGAAGATAGTTTCGAAGCTTTTGCAAGGAATGGAAAGTTTGAAGACTTTTCCTGAGG
CTGGTTTTAATGCAGATCAACGTTATGGTAAAAGAATCAATGACACATTTGAGACACGAGCACTTGTCGTTAAACGCTAT
GTCATACTTTATTTTATAGACGAAAGTAGAAAAGAGATTGTAGTCTCCCACATCTTTAGTTCTAAAAGCGACTATATCAA
GTTGTTATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10995.70 Da
• Isoelectric Point: 4.5576

>AT68876 WP_002889575.1 NZ_CP018187:44028-44315 [Streptococcus salivarius]
MTVVEKRVQVNFQTNPILLERARKIVKANNLDMSKSFNLFLETIVATEQIPVMTEDELLKERLFRQLKAEVAESVAEYQA
GNIIPLEEVKDEYNL

Nucleotide

• Length: 288 bp

>AT68876 NZ_CP018187:44028-44315 [Streptococcus salivarius]
ATGACTGTTGTAGAGAAGCGTGTTCAAGTAAATTTCCAAACTAACCCGATTTTGTTGGAAAGGGCAAGAAAAATTGTAAA
GGCAAATAATTTAGATATGAGTAAATCGTTTAATTTGTTTTTGGAGACGATTGTTGCTACCGAGCAAATACCAGTAATGA
CGGAGGATGAATTGCTAAAAGAAAGACTGTTTAGGCAGCTTAAAGCTGAAGTAGCAGAGAGTGTAGCTGAGTATCAGGCG
GGTAATATAATACCCCTTGAGGAGGTTAAGGATGAATACAACCTATAG

Structures

Toxin

• AlphaFold DB: J7T5K5

Antitoxin

• AlphaFold DB: F8LGC9